Manganese Catalyzed Asymmetric Transfer Hydrogenation of Ketones Using Chiral Oxamide Ligands

Jacob Schneekönig, Kathrin Junge, Matthias Beller

Research output: Contribution to journalArticlepeer-review

42 Scopus citations

Abstract

The asymmetric transfer hydrogenation of ketones using isopropyl alcohol (IPA) as hydrogen donor in the presence of novel manganese catalysts is explored. The selective and active systems are easily generated in situ from [MnBr(CO) 5 ] and inexpensive C 2 -symmeric bisoxalamide ligands. Under the optimized reaction conditions, the Mn-derived catalyst gave higher enantioselectivity compared with the related ruthenium catalyst.

Original languageEnglish
Pages (from-to)503-507
Number of pages5
JournalSynlett
Volume30
Issue number4
DOIs
StatePublished - 2019
Externally publishedYes

Keywords

  • asymmetric
  • chiral ligands
  • ketones
  • manganese
  • transfer hydrogenation

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