MALT1 directs B cell receptor-induced canonical nuclear factor-κB signaling selectively to the c-Rel subunit

Uta Ferch, Christian Meyer Zum Büschenfelde, Andreas Gewies, Elmar Wegener, Sandra Rauser, Christian Peschel, Daniel Krappmann, Jürgen Ruland

Research output: Contribution to journalArticlepeer-review

66 Scopus citations

Abstract

NF-κB (Rel) transcription factors control physiological and pathological immune cell function. The scaffold proteins Bcl-10 and MALT1 couple antigen-receptor signals to the canonical NF-κB pathway and are pivotal in lymphomagenesis. Here we found that Bcl-10 and MALT1 differentially regulated B cell receptor-induced activation of RelA and c-Rel. Bcl-10 was essential for recruitment of the kinase IKK into lipid rafts for the activation of RelA and c-Rel, for blocking apoptosis and for inducing division after B cell receptor ligation. In contrast, MALT1 participated in survival signaling but was not involved in IKK recruitment or activation and was dispensable for RelA induction and proliferation. MALT1 selectively activated c-Rel to control a distinct subprogram. Our results provide mechanistic insights into B cell receptor-induced survival and proliferation signals and demonstrate the selective control of c-Rel in the canonical NF-κB pathway.

Original languageEnglish
Pages (from-to)984-991
Number of pages8
JournalNature Immunology
Volume8
Issue number9
DOIs
StatePublished - Sep 2007
Externally publishedYes

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