Magnetic resonance of mouse models of cardiac disease

Karl Heinz Hiller, Christiane Waller, Axel Haase, Peter M. Jakob

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

10 Scopus citations

Abstract

In recent years magnetic resonance imaging (MRI) has become the noninvasive standard for the quantitative evaluation of cardiac function, masses, and infarct size. Wall motion analysis is used to display myocardial dysfunction and microcirculatory deficits can be displayed by perfusion imaging and quantification of the myocardial regional blood volume. Magnetic resonance spectroscopy (MRS) also provides quantitative information on cardiac energetics and, in combination with MRI, insights into cardiac structure and function. The use of both techniques permits complementary data collection within the same experimental setup. Nevertheless, it should be mentioned that MR does not directly visualize genes or gene product expression but morphological or bioenergetical outcomes of gene expression instead. In conclusion, cardiac MR is a valuable tool applicable to mouse phenotyping and, also, can be applied to assess the effects of therapeutic agents. Thus, MR of mouse models of cardiac disease has great potential to substantially contribute to the understanding of the underlying pathomechanisms and can help to evaluate new therapy options.

Original languageEnglish
Title of host publicationMolecular Imaging II
PublisherSpringer Science and Business Media, LLC
Pages245-257
Number of pages13
EditionPART2
ISBN (Print)9783540774495
DOIs
StatePublished - 2008
Externally publishedYes

Publication series

NameHandbook of Experimental Pharmacology
NumberPART2
Volume185
ISSN (Print)0171-2004
ISSN (Electronic)1865-0325

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