Magnetic Resonance Imaging of Coronary Arteries and Heart Valves in a Living Mouse: Techniques and Preliminary Results

Jan Ruff, Frank Wiesmann, Titus Lanz, Axel Haase

Research output: Contribution to journalArticlepeer-review

54 Scopus citations

Abstract

New investigations in MRI of a mouse heart showed high-contrast cardiac images and thereby the possibility of doing functional cardiac studies of in vivo mice. But is MRI, in addition, capable of visualizing microstructures such as the coronary arteries and the heart valves of a living mouse? To answer this question, 2D and 3D gradient echo sequences with and without flow compensation were used to image the coronary arteries. To increase signal-to-noise ratio, a birdcage resonator was optimized for mouse heart imaging. Contrast between blood and myocardium was achieved through the inflow effect. A segmented three-dimensional FLASH sequence acquired with a multiple overlap thin slab technique showed the best results. With this technique an isotropic resolution of 100 μm was achieved. The left coronary artery could be visualized up to the apex of the heart. This is demonstrated with short axis views and 3D surface reconstructions of the mouse heart. The four cardiac valves were also visible with the 3D method.

Original languageEnglish
Pages (from-to)290-296
Number of pages7
JournalJournal of Magnetic Resonance
Volume146
Issue number2
DOIs
StatePublished - Oct 2000
Externally publishedYes

Keywords

  • Cardiac valves
  • Coronary angiography
  • Magnetic resonance imaging
  • Mice
  • Three-dimensional

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