Magnetic aerosol targeting of nanoparticles to cancer: nanomagnetosols.

Carsten Rudolph; Bernhard Gleich; Andreas W. Flemmer

doi:10.1007/978-1-60761-609-2_18

Magnetic aerosol targeting of nanoparticles to cancer: nanomagnetosols.

Carsten Rudolph
, Bernhard Gleich
, Andreas W. Flemmer

University of Munich

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Inhalation of aerosols represents the most frequently used drug delivery method for the treatment of lung diseases. To further improve drug efficacy in the lungs, it may be advantageous to control aerosol deposition and target aerosols to diseased or disease-causing lung tissue and cellular structures in order to maximize drug potency and minimize side effects in unaffected tissue. We have recently investigated a novel method which brings aerosol delivery to an advanced level of specificity by making use of magnetic gradient fields to direct magnetizable aerosol droplets containing superparamagnetic iron oxide nanoparticles (SPION) specifically to desired regions of the lungs in mice. In this chapter, we will present a detailed description of this procedure for application in mice.

Original language	English
Pages (from-to)	267-280
Number of pages	14
Journal	Methods in molecular biology (Clifton, N.J.)
Volume	624
DOIs	https://doi.org/10.1007/978-1-60761-609-2_18
State	Published - 2010

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10.1007/978-1-60761-609-2_18

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title = "Magnetic aerosol targeting of nanoparticles to cancer: nanomagnetosols.",

abstract = "Inhalation of aerosols represents the most frequently used drug delivery method for the treatment of lung diseases. To further improve drug efficacy in the lungs, it may be advantageous to control aerosol deposition and target aerosols to diseased or disease-causing lung tissue and cellular structures in order to maximize drug potency and minimize side effects in unaffected tissue. We have recently investigated a novel method which brings aerosol delivery to an advanced level of specificity by making use of magnetic gradient fields to direct magnetizable aerosol droplets containing superparamagnetic iron oxide nanoparticles (SPION) specifically to desired regions of the lungs in mice. In this chapter, we will present a detailed description of this procedure for application in mice.",

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AU - Gleich, Bernhard

AU - Flemmer, Andreas W.

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AB - Inhalation of aerosols represents the most frequently used drug delivery method for the treatment of lung diseases. To further improve drug efficacy in the lungs, it may be advantageous to control aerosol deposition and target aerosols to diseased or disease-causing lung tissue and cellular structures in order to maximize drug potency and minimize side effects in unaffected tissue. We have recently investigated a novel method which brings aerosol delivery to an advanced level of specificity by making use of magnetic gradient fields to direct magnetizable aerosol droplets containing superparamagnetic iron oxide nanoparticles (SPION) specifically to desired regions of the lungs in mice. In this chapter, we will present a detailed description of this procedure for application in mice.

UR - https://www.scopus.com/pages/publications/77953428421

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JF - Methods in molecular biology (Clifton, N.J.)

ER -

Magnetic aerosol targeting of nanoparticles to cancer: nanomagnetosols.

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