Abstract
Current therapies in Parkinson's disease are primarily symptomatic, replacing lost striatal dopamine or restoring basal ganglia output to more physiological patterns. It is presently subject of intensive research to forestall disease progression by preventing further neurodegeneration (neuroprotection). Another experimental approach is to replace lost neurons by transplantation of dopamine producing cells or to restore dying neurons by the administration of neurotrophic factors (neurorestoration). There has been considerable progress especially in the field of gene therapy, that has moved from preclinical to clinical studies. In this review, we summarize current findings and discuss future directions in neuroprotective approaches as well as cell and gene therapy in Parkinson's disease.
| Translated title of the contribution | Parkinson's diseases - From basic research to future therapy |
|---|---|
| Original language | German |
| Pages (from-to) | 234-241 |
| Number of pages | 8 |
| Journal | Neuroforum |
| Volume | 14 |
| Issue number | 3 |
| State | Published - Sep 2008 |
| Externally published | Yes |