TY - JOUR
T1 - Lymphoid tissue structure and HIV-1 infection
T2 - Life or death for T cells
AU - Zeng, Ming
AU - Haase, Ashley T.
AU - Schacker, Timothy W.
N1 - Funding Information:
This work was supported NIH research grants AI054232, AI074340, and AI093319 to T.W.S. and AI028246, AI048484 and AI056997 to A.T.H. We thank C. O’Neill and T. Leonard for help in preparing the manuscript and figures.
PY - 2012/6
Y1 - 2012/6
N2 - Secondary lymphoid tissue (LT) structure facilitates immune responses and maintains homeostasis of T cells through production of survival factors, such as interleukin (IL)-7 that is 'posted' on the stromal fibroblastic reticular cell (FRC) network on which T cells traffic. Here, we examine the pathological changes that occur in LTs during HIV and simian immunodeficiency virus (SIV) infection. Immune activation leads to collagen deposition and loss of the FRC network itself. This decreases access to IL-7 and reduces the major source of IL-7, both of which deplete naïve T cells to limit immune reconstitution with antiretroviral treatment. We discuss the implications of LT structure damage for the timing of antiretroviral therapy and consider the development of adjunctive antifibrotic agents to improve immune reconstitution in HIV infection.
AB - Secondary lymphoid tissue (LT) structure facilitates immune responses and maintains homeostasis of T cells through production of survival factors, such as interleukin (IL)-7 that is 'posted' on the stromal fibroblastic reticular cell (FRC) network on which T cells traffic. Here, we examine the pathological changes that occur in LTs during HIV and simian immunodeficiency virus (SIV) infection. Immune activation leads to collagen deposition and loss of the FRC network itself. This decreases access to IL-7 and reduces the major source of IL-7, both of which deplete naïve T cells to limit immune reconstitution with antiretroviral treatment. We discuss the implications of LT structure damage for the timing of antiretroviral therapy and consider the development of adjunctive antifibrotic agents to improve immune reconstitution in HIV infection.
UR - http://www.scopus.com/inward/record.url?scp=84861702017&partnerID=8YFLogxK
U2 - 10.1016/j.it.2012.04.002
DO - 10.1016/j.it.2012.04.002
M3 - Review article
C2 - 22613276
AN - SCOPUS:84861702017
SN - 1471-4906
VL - 33
SP - 306
EP - 314
JO - Trends in Immunology
JF - Trends in Immunology
IS - 6
ER -
