Longitudinal changes of cerebral glucose metabolism in semantic dementia

J. Diehl-Schmid; T. Grimmer; A. Drzezga; S. Bornschein; R. Perneczky; H. Förstl; M. Schwaiger; A. Kurz

doi:10.1159/000095624

Longitudinal changes of cerebral glucose metabolism in semantic dementia

J. Diehl-Schmid
, T. Grimmer
, A. Drzezga
, S. Bornschein
, R. Perneczky
, H. Förstl
, M. Schwaiger
, A. Kurz

Technical University of Munich

Research output: Contribution to journal › Article › peer-review

39 Scopus citations

Abstract

Background: Semantic dementia (SD). Objective: To identify the pattern of decline of cerebral glucose metabolism in SD using cerebral ¹⁸F- fluoro-2-desoxy-D-glucose positron emission tomography scanning ( ¹⁸F-FDG-PET). Methods: Eight patients with SD underwent ¹⁸F-FDG-PET at baseline and at re-examination in average 15 months later. Results: Compared with healthy control subjects, patients with SD showed a significant asymmetrical (left > right) hypometabolism of the temporal lobes, particularly of the anterior poles, at baseline. At follow-up, we observed a deterioration of cognitive abilities. However, in addition to the temporal lobes no other cortical or subcortical region showed a significant reduction of glucose metabolism except the anterior cingulate cortex (pcorr < 0.05). Conclusion: Subtle functional changes suffice to produce significant neuropsychological deterioration.

Original language	English
Pages (from-to)	346-351
Number of pages	6
Journal	Dementia and Geriatric Cognitive Disorders
Volume	22
Issue number	4
DOIs	https://doi.org/10.1159/000095624
State	Published - Oct 2006

Keywords

Follow-up
Frontotemporal dementia
Glucose metabolism
Positron emission tomography
Semantic dementia

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10.1159/000095624

Cite this

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title = "Longitudinal changes of cerebral glucose metabolism in semantic dementia",

abstract = "Background: Semantic dementia (SD). Objective: To identify the pattern of decline of cerebral glucose metabolism in SD using cerebral 18F- fluoro-2-desoxy-D-glucose positron emission tomography scanning ( 18F-FDG-PET). Methods: Eight patients with SD underwent 18F-FDG-PET at baseline and at re-examination in average 15 months later. Results: Compared with healthy control subjects, patients with SD showed a significant asymmetrical (left > right) hypometabolism of the temporal lobes, particularly of the anterior poles, at baseline. At follow-up, we observed a deterioration of cognitive abilities. However, in addition to the temporal lobes no other cortical or subcortical region showed a significant reduction of glucose metabolism except the anterior cingulate cortex (pcorr < 0.05). Conclusion: Subtle functional changes suffice to produce significant neuropsychological deterioration.",

keywords = "Follow-up, Frontotemporal dementia, Glucose metabolism, Positron emission tomography, Semantic dementia",

author = "J. Diehl-Schmid and T. Grimmer and A. Drzezga and S. Bornschein and R. Perneczky and H. F{\"o}rstl and M. Schwaiger and A. Kurz",

year = "2006",

month = oct,

doi = "10.1159/000095624",

language = "English",

volume = "22",

pages = "346--351",

journal = "Dementia and Geriatric Cognitive Disorders",

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number = "4",

}

TY - JOUR

T1 - Longitudinal changes of cerebral glucose metabolism in semantic dementia

AU - Diehl-Schmid, J.

AU - Grimmer, T.

AU - Drzezga, A.

AU - Bornschein, S.

AU - Perneczky, R.

AU - Förstl, H.

AU - Schwaiger, M.

AU - Kurz, A.

PY - 2006/10

Y1 - 2006/10

N2 - Background: Semantic dementia (SD). Objective: To identify the pattern of decline of cerebral glucose metabolism in SD using cerebral 18F- fluoro-2-desoxy-D-glucose positron emission tomography scanning ( 18F-FDG-PET). Methods: Eight patients with SD underwent 18F-FDG-PET at baseline and at re-examination in average 15 months later. Results: Compared with healthy control subjects, patients with SD showed a significant asymmetrical (left > right) hypometabolism of the temporal lobes, particularly of the anterior poles, at baseline. At follow-up, we observed a deterioration of cognitive abilities. However, in addition to the temporal lobes no other cortical or subcortical region showed a significant reduction of glucose metabolism except the anterior cingulate cortex (pcorr < 0.05). Conclusion: Subtle functional changes suffice to produce significant neuropsychological deterioration.

AB - Background: Semantic dementia (SD). Objective: To identify the pattern of decline of cerebral glucose metabolism in SD using cerebral 18F- fluoro-2-desoxy-D-glucose positron emission tomography scanning ( 18F-FDG-PET). Methods: Eight patients with SD underwent 18F-FDG-PET at baseline and at re-examination in average 15 months later. Results: Compared with healthy control subjects, patients with SD showed a significant asymmetrical (left > right) hypometabolism of the temporal lobes, particularly of the anterior poles, at baseline. At follow-up, we observed a deterioration of cognitive abilities. However, in addition to the temporal lobes no other cortical or subcortical region showed a significant reduction of glucose metabolism except the anterior cingulate cortex (pcorr < 0.05). Conclusion: Subtle functional changes suffice to produce significant neuropsychological deterioration.

KW - Follow-up

KW - Frontotemporal dementia

KW - Glucose metabolism

KW - Positron emission tomography

KW - Semantic dementia

UR - https://www.scopus.com/pages/publications/33750458345

U2 - 10.1159/000095624

DO - 10.1159/000095624

M3 - Article

C2 - 16954690

AN - SCOPUS:33750458345

SN - 1420-8008

VL - 22

SP - 346

EP - 351

JO - Dementia and Geriatric Cognitive Disorders

JF - Dementia and Geriatric Cognitive Disorders

IS - 4

ER -

Longitudinal changes of cerebral glucose metabolism in semantic dementia

Abstract

Keywords

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