Long interspersed nuclear elements safeguard neural progenitors from precocious differentiation

Tomohisa Toda; Tracy A. Bedrosian; Simon T. Schafer; Michael S. Cuoco; Sara B. Linker; Saeed Ghassemzadeh; Lisa Mitchell; Jack T. Whiteley; Nicole Novaresi; Aidan H. McDonald; Iryna S. Gallina; Hyojung Yoon; Mark E. Hester; Monique Pena; Christina Lim; Emelia Suljic; Abed AlFatah Mansour; Matthieu Boulard; Sarah L. Parylak; Fred H. Gage

doi:10.1016/j.celrep.2024.113774

Long interspersed nuclear elements safeguard neural progenitors from precocious differentiation

Tomohisa Toda, Tracy A. Bedrosian, Simon T. Schafer, Michael S. Cuoco, Sara B. Linker, Saeed Ghassemzadeh, Lisa Mitchell, Jack T. Whiteley, Nicole Novaresi, Aidan H. McDonald, Iryna S. Gallina, Hyojung Yoon, Mark E. Hester, Monique Pena, Christina Lim, Emelia Suljic, Abed AlFatah Mansour, Matthieu Boulard, Sarah L. Parylak, Fred H. Gage

Department of Psychiatry and Psychotherapy

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Long interspersed nuclear element-1 (L1 or LINE-1) is a highly abundant mobile genetic element in both humans and mice, comprising almost 20% of each genome. L1s are silenced by several mechanisms, as their uncontrolled expression has the potential to induce genomic instability. However, L1s are paradoxically expressed at high levels in differentiating neural progenitor cells. Using in vitro and in vivo techniques to modulate L1 expression, we report that L1s play a critical role in both human and mouse brain development by regulating the rate of neural differentiation in a reverse-transcription-independent manner.

Original language	English
Article number	113774
Journal	Cell Reports
Volume	43
Issue number	2
DOIs	https://doi.org/10.1016/j.celrep.2024.113774
State	Published - 27 Feb 2024

Keywords

brain development
CP: Developmental biology
CP: Neuroscience
L1
LINE-1
neural progenitor cells
repetitive elements

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10.1016/j.celrep.2024.113774

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Toda, T., Bedrosian, T. A., Schafer, S. T., Cuoco, M. S., Linker, S. B., Ghassemzadeh, S., Mitchell, L., Whiteley, J. T., Novaresi, N., McDonald, A. H., Gallina, I. S., Yoon, H., Hester, M. E., Pena, M., Lim, C., Suljic, E., AlFatah Mansour, A., Boulard, M., Parylak, S. L., & Gage, F. H. (2024). Long interspersed nuclear elements safeguard neural progenitors from precocious differentiation. Cell Reports, 43(2), Article 113774. https://doi.org/10.1016/j.celrep.2024.113774

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title = "Long interspersed nuclear elements safeguard neural progenitors from precocious differentiation",

abstract = "Long interspersed nuclear element-1 (L1 or LINE-1) is a highly abundant mobile genetic element in both humans and mice, comprising almost 20% of each genome. L1s are silenced by several mechanisms, as their uncontrolled expression has the potential to induce genomic instability. However, L1s are paradoxically expressed at high levels in differentiating neural progenitor cells. Using in vitro and in vivo techniques to modulate L1 expression, we report that L1s play a critical role in both human and mouse brain development by regulating the rate of neural differentiation in a reverse-transcription-independent manner.",

keywords = "brain development, CP: Developmental biology, CP: Neuroscience, L1, LINE-1, neural progenitor cells, repetitive elements",

author = "Tomohisa Toda and Bedrosian, {Tracy A.} and Schafer, {Simon T.} and Cuoco, {Michael S.} and Linker, {Sara B.} and Saeed Ghassemzadeh and Lisa Mitchell and Whiteley, {Jack T.} and Nicole Novaresi and McDonald, {Aidan H.} and Gallina, {Iryna S.} and Hyojung Yoon and Hester, {Mark E.} and Monique Pena and Christina Lim and Emelia Suljic and {AlFatah Mansour}, Abed and Matthieu Boulard and Parylak, {Sarah L.} and Gage, {Fred H.}",

note = "Publisher Copyright: {\textcopyright} 2024 The Author(s)",

year = "2024",

month = feb,

day = "27",

doi = "10.1016/j.celrep.2024.113774",

language = "English",

volume = "43",

journal = "Cell Reports",

issn = "2639-1856",

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Toda, T, Bedrosian, TA, Schafer, ST, Cuoco, MS, Linker, SB, Ghassemzadeh, S, Mitchell, L, Whiteley, JT, Novaresi, N, McDonald, AH, Gallina, IS, Yoon, H, Hester, ME, Pena, M, Lim, C, Suljic, E, AlFatah Mansour, A, Boulard, M, Parylak, SL & Gage, FH 2024, 'Long interspersed nuclear elements safeguard neural progenitors from precocious differentiation', Cell Reports, vol. 43, no. 2, 113774. https://doi.org/10.1016/j.celrep.2024.113774

TY - JOUR

T1 - Long interspersed nuclear elements safeguard neural progenitors from precocious differentiation

AU - Toda, Tomohisa

AU - Bedrosian, Tracy A.

AU - Schafer, Simon T.

AU - Cuoco, Michael S.

AU - Linker, Sara B.

AU - Ghassemzadeh, Saeed

AU - Mitchell, Lisa

AU - Whiteley, Jack T.

AU - Novaresi, Nicole

AU - McDonald, Aidan H.

AU - Gallina, Iryna S.

AU - Yoon, Hyojung

AU - Hester, Mark E.

AU - Pena, Monique

AU - Lim, Christina

AU - Suljic, Emelia

AU - AlFatah Mansour, Abed

AU - Boulard, Matthieu

AU - Parylak, Sarah L.

AU - Gage, Fred H.

PY - 2024/2/27

Y1 - 2024/2/27

N2 - Long interspersed nuclear element-1 (L1 or LINE-1) is a highly abundant mobile genetic element in both humans and mice, comprising almost 20% of each genome. L1s are silenced by several mechanisms, as their uncontrolled expression has the potential to induce genomic instability. However, L1s are paradoxically expressed at high levels in differentiating neural progenitor cells. Using in vitro and in vivo techniques to modulate L1 expression, we report that L1s play a critical role in both human and mouse brain development by regulating the rate of neural differentiation in a reverse-transcription-independent manner.

AB - Long interspersed nuclear element-1 (L1 or LINE-1) is a highly abundant mobile genetic element in both humans and mice, comprising almost 20% of each genome. L1s are silenced by several mechanisms, as their uncontrolled expression has the potential to induce genomic instability. However, L1s are paradoxically expressed at high levels in differentiating neural progenitor cells. Using in vitro and in vivo techniques to modulate L1 expression, we report that L1s play a critical role in both human and mouse brain development by regulating the rate of neural differentiation in a reverse-transcription-independent manner.

KW - brain development

KW - CP: Developmental biology

KW - CP: Neuroscience

KW - L1

KW - LINE-1

KW - neural progenitor cells

KW - repetitive elements

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U2 - 10.1016/j.celrep.2024.113774

DO - 10.1016/j.celrep.2024.113774

M3 - Article

C2 - 38349791

AN - SCOPUS:85184797971

SN - 2639-1856

VL - 43

JO - Cell Reports

JF - Cell Reports

IS - 2

M1 - 113774

ER -

Long interspersed nuclear elements safeguard neural progenitors from precocious differentiation

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Keywords

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