Localized Inhibition of Protein Phosphatase 1 by NUAK1 Promotes Spliceosome Activity and Reveals a MYC-Sensitive Feedback Control of Transcription

Giacomo Cossa; Isabelle Roeschert; Florian Prinz; Apoorva Baluapuri; Raphael Silveira Vidal; Christina Schülein-Völk; Yun Chien Chang; Carsten Patrick Ade; Guido Mastrobuoni; Cyrille Girard; Lars Wortmann; Susanne Walz; Reinhard Lührmann; Stefan Kempa; Bernhard Kuster; Elmar Wolf; Dominik Mumberg; Martin Eilers

doi:10.1016/j.molcel.2020.01.008

Localized Inhibition of Protein Phosphatase 1 by NUAK1 Promotes Spliceosome Activity and Reveals a MYC-Sensitive Feedback Control of Transcription

Giacomo Cossa, Isabelle Roeschert, Florian Prinz, Apoorva Baluapuri, Raphael Silveira Vidal, Christina Schülein-Völk, Yun Chien Chang, Carsten Patrick Ade, Guido Mastrobuoni, Cyrille Girard, Lars Wortmann, Susanne Walz, Reinhard Lührmann, Stefan Kempa, Bernhard Kuster, Elmar Wolf, Dominik Mumberg, Martin Eilers

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Abstract

Tumors displaying high MYC levels depend on the NUAK1 kinase. Cossa et al. show that NUAK1 binds protein phosphatase 1 (PP1) and its regulatory subunit PNUTS. They show that this complex associates with the splicing machinery and provides a feedback control of transcription that can be overridden by deregulated MYC.

Original language	English
Pages (from-to)	1322-1339.e11
Journal	Molecular Cell
Volume	77
Issue number	6
DOIs	https://doi.org/10.1016/j.molcel.2020.01.008
State	Published - 19 Mar 2020

Keywords

ARK5
MYC
NUAK1
PNUTS
PP1
Protein Phosphatase 1
Spliceosome

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10.1016/j.molcel.2020.01.008

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Cossa, G., Roeschert, I., Prinz, F., Baluapuri, A., Silveira Vidal, R., Schülein-Völk, C., Chang, Y. C., Ade, C. P., Mastrobuoni, G., Girard, C., Wortmann, L., Walz, S., Lührmann, R., Kempa, S., Kuster, B., Wolf, E., Mumberg, D., & Eilers, M. (2020). Localized Inhibition of Protein Phosphatase 1 by NUAK1 Promotes Spliceosome Activity and Reveals a MYC-Sensitive Feedback Control of Transcription. Molecular Cell, 77(6), 1322-1339.e11. https://doi.org/10.1016/j.molcel.2020.01.008

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title = "Localized Inhibition of Protein Phosphatase 1 by NUAK1 Promotes Spliceosome Activity and Reveals a MYC-Sensitive Feedback Control of Transcription",

abstract = "Tumors displaying high MYC levels depend on the NUAK1 kinase. Cossa et al. show that NUAK1 binds protein phosphatase 1 (PP1) and its regulatory subunit PNUTS. They show that this complex associates with the splicing machinery and provides a feedback control of transcription that can be overridden by deregulated MYC.",

keywords = "ARK5, MYC, NUAK1, PNUTS, PP1, Protein Phosphatase 1, Spliceosome",

author = "Giacomo Cossa and Isabelle Roeschert and Florian Prinz and Apoorva Baluapuri and {Silveira Vidal}, Raphael and Christina Sch{\"u}lein-V{\"o}lk and Chang, {Yun Chien} and Ade, {Carsten Patrick} and Guido Mastrobuoni and Cyrille Girard and Lars Wortmann and Susanne Walz and Reinhard L{\"u}hrmann and Stefan Kempa and Bernhard Kuster and Elmar Wolf and Dominik Mumberg and Martin Eilers",

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year = "2020",

month = mar,

day = "19",

doi = "10.1016/j.molcel.2020.01.008",

language = "English",

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Cossa, G, Roeschert, I, Prinz, F, Baluapuri, A, Silveira Vidal, R, Schülein-Völk, C, Chang, YC, Ade, CP, Mastrobuoni, G, Girard, C, Wortmann, L, Walz, S, Lührmann, R, Kempa, S, Kuster, B, Wolf, E, Mumberg, D & Eilers, M 2020, 'Localized Inhibition of Protein Phosphatase 1 by NUAK1 Promotes Spliceosome Activity and Reveals a MYC-Sensitive Feedback Control of Transcription', Molecular Cell, vol. 77, no. 6, pp. 1322-1339.e11. https://doi.org/10.1016/j.molcel.2020.01.008

TY - JOUR

T1 - Localized Inhibition of Protein Phosphatase 1 by NUAK1 Promotes Spliceosome Activity and Reveals a MYC-Sensitive Feedback Control of Transcription

AU - Cossa, Giacomo

AU - Roeschert, Isabelle

AU - Prinz, Florian

AU - Baluapuri, Apoorva

AU - Silveira Vidal, Raphael

AU - Schülein-Völk, Christina

AU - Chang, Yun Chien

AU - Ade, Carsten Patrick

AU - Mastrobuoni, Guido

AU - Girard, Cyrille

AU - Wortmann, Lars

AU - Walz, Susanne

AU - Lührmann, Reinhard

AU - Kempa, Stefan

AU - Kuster, Bernhard

AU - Wolf, Elmar

AU - Mumberg, Dominik

AU - Eilers, Martin

PY - 2020/3/19

Y1 - 2020/3/19

N2 - Tumors displaying high MYC levels depend on the NUAK1 kinase. Cossa et al. show that NUAK1 binds protein phosphatase 1 (PP1) and its regulatory subunit PNUTS. They show that this complex associates with the splicing machinery and provides a feedback control of transcription that can be overridden by deregulated MYC.

AB - Tumors displaying high MYC levels depend on the NUAK1 kinase. Cossa et al. show that NUAK1 binds protein phosphatase 1 (PP1) and its regulatory subunit PNUTS. They show that this complex associates with the splicing machinery and provides a feedback control of transcription that can be overridden by deregulated MYC.

KW - ARK5

KW - MYC

KW - NUAK1

KW - PNUTS

KW - PP1

KW - Protein Phosphatase 1

KW - Spliceosome

UR - http://www.scopus.com/inward/record.url?scp=85079816556&partnerID=8YFLogxK

U2 - 10.1016/j.molcel.2020.01.008

DO - 10.1016/j.molcel.2020.01.008

M3 - Article

C2 - 32006464

AN - SCOPUS:85079816556

SN - 1097-2765

VL - 77

SP - 1322-1339.e11

JO - Molecular Cell

JF - Molecular Cell

IS - 6

ER -

Localized Inhibition of Protein Phosphatase 1 by NUAK1 Promotes Spliceosome Activity and Reveals a MYC-Sensitive Feedback Control of Transcription

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Keywords

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