Abstract
Lipase from Candida cylindracea catalyzes the acidolysis between racemic 2-methylalkanoates and fatty acids in heptane with a preference for the (S)-configurated esters. Velocity and enantioselectivity of the acyl transfer are strongly influenced by the structures of the initial substrates. The potential of this strategy for kinetic resolution of the enantiomers of chiral 2-methylalkanoates is demonstrated. Limitations of the procedure due to the reversible character of the reaction are discussed.
| Original language | English |
|---|---|
| Pages (from-to) | 146-150 |
| Number of pages | 5 |
| Journal | Journal of the American Oil Chemists' Society |
| Volume | 69 |
| Issue number | 2 |
| DOIs | |
| State | Published - Feb 1992 |
| Externally published | Yes |
Keywords
- 2-methylalkanoates
- Acidolysis
- chirality
- enantioselectivity
- esterification
- kinetic resolution
- lipase
- transesterification
Fingerprint
Dive into the research topics of 'Lipase-catalyzed enantioselective acidolysis of chiral 2-methylalkanoates'. Together they form a unique fingerprint.Cite this
- APA
- Author
- BIBTEX
- Harvard
- Standard
- RIS
- Vancouver