Limited resection and free jejunal graft interposition for squamous cell carcinoma of the cervical oesophagus

K. Ott, F. Lordick, M. Molls, H. Bartels, E. Biemer, J. R. Siewert

Research output: Contribution to journalArticlepeer-review

61 Scopus citations

Abstract

Background: Therapeutic strategics for cervical oesophageal squamous cell carcinoma (SCC) are controversial. Treatment options range from definitive radiotherapy to multimodal treatment. Outcome after limited resection and reconstruction with a free jejunal graft interposition was evaluated retrospectively. Methods: Patients with clinical Tl-4 Nx MO tumours treated between 1986 and 2006 were included. Results; Of 109 patients, 94 underwent preoperative chemoradiotherapy and 15 had a primary resection. Complete or partial preservation of the larynx was achieved in 93 patients (85.3 per cent). Minor and major complications occurred in 74.3 per cent, with 44-0 per cent of all patients having more than one complication. Reoperation was necessary in 29.4 per cent. The 30-day mortality rate was 1.8 per cent, and the in-hospital mortality rate 2.8 per cent. The complete RO resection rate was 72.5 per cent. Median overall survival was 34.3 months; 1-, 3- and 5-year survival rates were 83.8, 47.0 and 47.0 per cent respectively. Survival was not influenced by complications (P = 0.401) or reoperation (P = 0.428). Conclusion: Despite high complication and reoperation rates, the mortality rate was low, even after preoperative chemoradiation. This complex surgical strategy is a treatment option for cervical SCC in oncological centres with an infrastructure providing multidisciplinary management.

Original languageEnglish
Pages (from-to)258-266
Number of pages9
JournalBritish Journal of Surgery
Volume96
Issue number3
DOIs
StatePublished - Mar 2009

Fingerprint

Dive into the research topics of 'Limited resection and free jejunal graft interposition for squamous cell carcinoma of the cervical oesophagus'. Together they form a unique fingerprint.

Cite this