Limited agreement between biomarkers of neuronal injury at different stages of Alzheimer's disease

Panagiotis Alexopoulos; Laura Kriett; Bernhard Haller; Elisabeth Klupp; Katherine Gray; Timo Grimmer; Nikolaos Laskaris; Stefan Förster; Robert Perneczky; Alexander Kurz; Alexander Drzezga; Andreas Fellgiebel; Igor Yakushev

doi:10.1016/j.jalz.2014.03.006

Limited agreement between biomarkers of neuronal injury at different stages of Alzheimer's disease

Panagiotis Alexopoulos, Laura Kriett, Bernhard Haller, Elisabeth Klupp, Katherine Gray, Timo Grimmer, Nikolaos Laskaris, Stefan Förster, Robert Perneczky, Alexander Kurz, Alexander Drzezga, Andreas Fellgiebel, Igor Yakushev

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Abstract

New diagnostic criteria for Alzheimer's disease (AD) treat different biomarkers of neuronal injury as equivalent. Here, we quantified the degree of agreement between hippocampal volume on structural magnetic resonance imaging, regional glucose metabolism on positron emission tomography, and levels of phosphorylated tau in cerebrospinal fluid (CSF) in 585 subjects from all phases of the AD Neuroimaging Initiative. The overall chance-corrected agreement was poor (Cohen κ, 0.24-0.34), in accord with a high rate of conflicting findings (26%-41%). Neither diagnosis nor APOE ε4 status significantly influenced the distribution of agreement between the biomarkers. The degree of agreement tended to be higher in individuals with abnormal versus normal CSF β-amyloid (Aβ_1-42) levels. Prospective diagnostic criteria for AD should address the relative importance of markers of neuronal injury and elaborate a way of dealing with conflicting biomarker findings.

Original language	English
Pages (from-to)	684-689
Number of pages	6
Journal	Alzheimer's and Dementia
Volume	10
Issue number	6
DOIs	https://doi.org/10.1016/j.jalz.2014.03.006
State	Published - 1 Nov 2014

Keywords

Agreement
Dementia
Diagnostic criteria
FDG-PET
Hippocampal atrophy
Tau

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.jalz.2014.03.006

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title = "Limited agreement between biomarkers of neuronal injury at different stages of Alzheimer's disease",

abstract = "New diagnostic criteria for Alzheimer's disease (AD) treat different biomarkers of neuronal injury as equivalent. Here, we quantified the degree of agreement between hippocampal volume on structural magnetic resonance imaging, regional glucose metabolism on positron emission tomography, and levels of phosphorylated tau in cerebrospinal fluid (CSF) in 585 subjects from all phases of the AD Neuroimaging Initiative. The overall chance-corrected agreement was poor (Cohen κ, 0.24-0.34), in accord with a high rate of conflicting findings (26%-41%). Neither diagnosis nor APOE ε4 status significantly influenced the distribution of agreement between the biomarkers. The degree of agreement tended to be higher in individuals with abnormal versus normal CSF β-amyloid (Aβ1-42) levels. Prospective diagnostic criteria for AD should address the relative importance of markers of neuronal injury and elaborate a way of dealing with conflicting biomarker findings.",

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AU - Alexopoulos, Panagiotis

AU - Kriett, Laura

AU - Haller, Bernhard

AU - Klupp, Elisabeth

AU - Gray, Katherine

AU - Grimmer, Timo

AU - Laskaris, Nikolaos

AU - Förster, Stefan

AU - Perneczky, Robert

AU - Kurz, Alexander

AU - Drzezga, Alexander

AU - Fellgiebel, Andreas

AU - Yakushev, Igor

PY - 2014/11/1

Y1 - 2014/11/1

N2 - New diagnostic criteria for Alzheimer's disease (AD) treat different biomarkers of neuronal injury as equivalent. Here, we quantified the degree of agreement between hippocampal volume on structural magnetic resonance imaging, regional glucose metabolism on positron emission tomography, and levels of phosphorylated tau in cerebrospinal fluid (CSF) in 585 subjects from all phases of the AD Neuroimaging Initiative. The overall chance-corrected agreement was poor (Cohen κ, 0.24-0.34), in accord with a high rate of conflicting findings (26%-41%). Neither diagnosis nor APOE ε4 status significantly influenced the distribution of agreement between the biomarkers. The degree of agreement tended to be higher in individuals with abnormal versus normal CSF β-amyloid (Aβ1-42) levels. Prospective diagnostic criteria for AD should address the relative importance of markers of neuronal injury and elaborate a way of dealing with conflicting biomarker findings.

AB - New diagnostic criteria for Alzheimer's disease (AD) treat different biomarkers of neuronal injury as equivalent. Here, we quantified the degree of agreement between hippocampal volume on structural magnetic resonance imaging, regional glucose metabolism on positron emission tomography, and levels of phosphorylated tau in cerebrospinal fluid (CSF) in 585 subjects from all phases of the AD Neuroimaging Initiative. The overall chance-corrected agreement was poor (Cohen κ, 0.24-0.34), in accord with a high rate of conflicting findings (26%-41%). Neither diagnosis nor APOE ε4 status significantly influenced the distribution of agreement between the biomarkers. The degree of agreement tended to be higher in individuals with abnormal versus normal CSF β-amyloid (Aβ1-42) levels. Prospective diagnostic criteria for AD should address the relative importance of markers of neuronal injury and elaborate a way of dealing with conflicting biomarker findings.

KW - Agreement

KW - Dementia

KW - Diagnostic criteria

KW - FDG-PET

KW - Hippocampal atrophy

KW - Tau

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SN - 1552-5260

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EP - 689

JO - Alzheimer's and Dementia

JF - Alzheimer's and Dementia

IS - 6

ER -

Limited agreement between biomarkers of neuronal injury at different stages of Alzheimer's disease

Abstract

Keywords

UN SDGs

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