TY - JOUR
T1 - Lifetime study in mice after acute low-dose ionizing radiation
T2 - a multifactorial study with special focus on cataract risk
AU - Dalke, Claudia
AU - Neff, Frauke
AU - Bains, Savneet Kaur
AU - Bright, Scott
AU - Lord, Deborah
AU - Reitmeir, Peter
AU - Rößler, Ute
AU - Samaga, Daniel
AU - Unger, Kristian
AU - Braselmann, Herbert
AU - Wagner, Florian
AU - Greiter, Matthias
AU - Gomolka, Maria
AU - Hornhardt, Sabine
AU - Kunze, Sarah
AU - Kempf, Stefan J.
AU - Garrett, Lillian
AU - Hölter, Sabine M.
AU - Wurst, Wolfgang
AU - Rosemann, Michael
AU - Azimzadeh, Omid
AU - Tapio, Soile
AU - Aubele, Michaela
AU - Theis, Fabian
AU - Hoeschen, Christoph
AU - Slijepcevic, Predrag
AU - Kadhim, Munira
AU - Atkinson, Michael
AU - Zitzelsberger, Horst
AU - Kulka, Ulrike
AU - Graw, Jochen
N1 - Publisher Copyright:
© 2018, The Author(s).
PY - 2018/5/1
Y1 - 2018/5/1
N2 - Because of the increasing application of ionizing radiation in medicine, quantitative data on effects of low-dose radiation are needed to optimize radiation protection, particularly with respect to cataract development. Using mice as mammalian animal model, we applied a single dose of 0, 0.063, 0.125 and 0.5 Gy at 10 weeks of age, determined lens opacities for up to 2 years and compared it with overall survival, cytogenetic alterations and cancer development. The highest dose was significantly associated with increased body weight and reduced survival rate. Chromosomal aberrations in bone marrow cells showed a dose-dependent increase 12 months after irradiation. Pathological screening indicated a dose-dependent risk for several types of tumors. Scheimpflug imaging of the lens revealed a significant dose-dependent effect of 1% of lens opacity. Comparison of different biological end points demonstrated long-term effects of low-dose irradiation for several biological end points.
AB - Because of the increasing application of ionizing radiation in medicine, quantitative data on effects of low-dose radiation are needed to optimize radiation protection, particularly with respect to cataract development. Using mice as mammalian animal model, we applied a single dose of 0, 0.063, 0.125 and 0.5 Gy at 10 weeks of age, determined lens opacities for up to 2 years and compared it with overall survival, cytogenetic alterations and cancer development. The highest dose was significantly associated with increased body weight and reduced survival rate. Chromosomal aberrations in bone marrow cells showed a dose-dependent increase 12 months after irradiation. Pathological screening indicated a dose-dependent risk for several types of tumors. Scheimpflug imaging of the lens revealed a significant dose-dependent effect of 1% of lens opacity. Comparison of different biological end points demonstrated long-term effects of low-dose irradiation for several biological end points.
KW - Low-dose radiation
KW - Mouse
KW - Radiation-induced cataract
KW - Scheimpflug analysis
UR - http://www.scopus.com/inward/record.url?scp=85040337867&partnerID=8YFLogxK
U2 - 10.1007/s00411-017-0728-z
DO - 10.1007/s00411-017-0728-z
M3 - Article
C2 - 29327260
AN - SCOPUS:85040337867
SN - 0301-634X
VL - 57
SP - 99
EP - 113
JO - Radiation and Environmental Biophysics
JF - Radiation and Environmental Biophysics
IS - 2
ER -