Lifestyle, Ernährung, Sport und ihre Bedeutung für die Prävention hereditärer Krebserkankungen in der Gynäkologie

Translated title of the contribution: Lifestyle, nutrition, sport, and their importance in prevention of hereditary cancer in women

Marion Kiechle, Sabine Grill

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

In Germany, 37% of all cancer cases are attributed to an unhealthy lifestyle and thus could be avoided. This unhealthy lifestyle is characterized by increasing rates of obesity, lack of physical activity, and unhealthy nutritional behavior. These factors, together with alcohol consumption and nicotine abuse, are considered to be key factors in the development of a variety of cancer diseases, particularly breast cancer. Moreover, evidence suggests that even in women with an inherited predisposition to breast cancer as the result of a mutation in one of the BRCA genes, physical activity and normal body weight might result in a reduction of cancer risk. The LIBRE study is the first prospective-randomized lifestyle intervention study worldwide for carriers of a pathogenic BRCA1/2 germline mutation, aiming to investigate the impact of behavior modification on breast cancer incidence, prognosis, and mortality. Targeted prevention and additional treatment choices for hereditary and sporadic breast cancer are the main future objectives described in this work.

Translated title of the contributionLifestyle, nutrition, sport, and their importance in prevention of hereditary cancer in women
Original languageGerman
Pages (from-to)756-760
Number of pages5
JournalGynakologe
Volume53
Issue number11
DOIs
StatePublished - Nov 2020

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