Life with 6000 genes

A. Goffeau; G. Barrell; H. Bussey; R. W. Davis; B. Dujon; H. Feldmann; F. Galibert; J. D. Hoheisel; C. Jacq; M. Johnston; E. J. Louis; H. W. Mewes; Y. Murakami; P. Philippsen; H. Tettelin; S. G. Oliver

doi:10.1126/science.274.5287.546

Life with 6000 genes

A. Goffeau, G. Barrell, H. Bussey, R. W. Davis, B. Dujon, H. Feldmann, F. Galibert, J. D. Hoheisel, C. Jacq, M. Johnston, E. J. Louis, H. W. Mewes, Y. Murakami, P. Philippsen, H. Tettelin, S. G. Oliver

Life Sciences

Research output: Contribution to journal › Article › peer-review

3504 Scopus citations

Abstract

The genome of the yeast Saccharomyces cerevisiae has been completely sequenced through a worldwide collaboration. The sequence of 12,068 kilobases defines 5885 potential protein-encoding genes, approximately 140 genes specifying ribosomal RNA, 40 genes for small nuclear RNA molecules, and 275 transfer RNA genes. In addition, the complete sequence provides information about the higher order organization of yeast's 16 chromosomes and allows some insight into their evolutionary history. The genome shows a considerable amount of apparent genetic redundancy, and one of the major problems to be tackled during the next stage of the yeast genome project is to elucidate the biological functions of all of these genes.

Original language	English
Pages (from-to)	546-567
Number of pages	22
Journal	Science
Volume	274
Issue number	5287
DOIs	https://doi.org/10.1126/science.274.5287.546
State	Published - 1996

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abstract = "The genome of the yeast Saccharomyces cerevisiae has been completely sequenced through a worldwide collaboration. The sequence of 12,068 kilobases defines 5885 potential protein-encoding genes, approximately 140 genes specifying ribosomal RNA, 40 genes for small nuclear RNA molecules, and 275 transfer RNA genes. In addition, the complete sequence provides information about the higher order organization of yeast's 16 chromosomes and allows some insight into their evolutionary history. The genome shows a considerable amount of apparent genetic redundancy, and one of the major problems to be tackled during the next stage of the yeast genome project is to elucidate the biological functions of all of these genes.",

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T1 - Life with 6000 genes

AU - Goffeau, A.

AU - Barrell, G.

AU - Bussey, H.

AU - Davis, R. W.

AU - Dujon, B.

AU - Feldmann, H.

AU - Galibert, F.

AU - Hoheisel, J. D.

AU - Jacq, C.

AU - Johnston, M.

AU - Louis, E. J.

AU - Mewes, H. W.

AU - Murakami, Y.

AU - Philippsen, P.

AU - Tettelin, H.

AU - Oliver, S. G.

PY - 1996

Y1 - 1996

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AB - The genome of the yeast Saccharomyces cerevisiae has been completely sequenced through a worldwide collaboration. The sequence of 12,068 kilobases defines 5885 potential protein-encoding genes, approximately 140 genes specifying ribosomal RNA, 40 genes for small nuclear RNA molecules, and 275 transfer RNA genes. In addition, the complete sequence provides information about the higher order organization of yeast's 16 chromosomes and allows some insight into their evolutionary history. The genome shows a considerable amount of apparent genetic redundancy, and one of the major problems to be tackled during the next stage of the yeast genome project is to elucidate the biological functions of all of these genes.

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VL - 274

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Life with 6000 genes

Abstract

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