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Life Is Degrading-Thanks to Some Zomes

  • University of Tennessee
  • University of Tübingen

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Three structurally related protein complexes, the COP9 signalosome, the proteasome lid, and the eukaryotic translation initiation factor 3, are revealing new insights into developmental processes and into cell cycle control in healthy cells and cells exposed to genotoxic stress. Newly discovered cullin-RING E3 ubiquitin ligases assembled on the CUL4 platform may provide links between DNA replication, chromatin, and proteolysis.

Original languageEnglish
Pages (from-to)621-629
Number of pages9
JournalMolecular Cell
Volume23
Issue number5
DOIs
StatePublished - 1 Sep 2006
Externally publishedYes

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