LH-RH receptors in the human pancreas - Basis for antihormonal treatment in ductal carcinoma of the pancreas

Helmut Friess, Markus Büchler, Ludwig Kiesel, Martin Krüger, Hans G. Beger

Research output: Contribution to journalArticlepeer-review

41 Scopus citations

Abstract

LH-RH-, estrogen-, and progesterone-receptor binding was measured in the human pancreas of patients with ductal pancreatic cancer (n = 23) and chronic pancreatitis (n = 15), and of organ donors (n = 11). Receptor analysis was determined by incubation of the homogenized tissues with estrogen, progesterone, and the LH-RH analog buserelin labeled with iodine-125. Only one biopsy (9%) from normal pancreas had an LH-RH-receptor concentration > fmol/mg membrane protein. LH-RH binding levels > fmol/mg were detected in 67% of patients with chronic pancreatitis and in 57% of patients with pancreatic cancer. Progesterone levels > 15 fmol/mg membrane protein were found in 36% of normal pancreas, in 27% of chronic pancreatitis, and in 17% of pancreatic cancer cases, respectively. The highest concentration of estrogen receptors (> 15 fmol/mg membrane protein) was seen in normal pancreas (73%). The increase in LH-RH-receptor concentration in chronic pancreatitis and pancreatic cancer seems to be unspecific, but might be of benefit for antiproliferative treatment in pancreatic cancer.

Original languageEnglish
Pages (from-to)151-159
Number of pages9
JournalInternational Journal of Pancreatology
Volume10
Issue number2
DOIs
StatePublished - Oct 1991
Externally publishedYes

Keywords

  • LH-RH
  • Receptors
  • chronic pancreatitis
  • estrogen, progesterone
  • pancreatic cancer

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