Lethal outcome of granulomatous acanthamoebic encephalitis in a man who was human immunodeficiency virus-positive: A case report

Stefanie Geith, Julia Walochnik, Franz Prantl, Stefan Sack, Florian Eyer

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Background: Acanthamoeba species can cause disseminating infections in immunocompromised individuals. Case presentation: Here, we report a case of granulomatous acanthamoebic encephalitis with a lethal outcome in a 54-year-old German man who was human immunodeficiency virus-positive. The diagnosis was based on symptoms of progressive neurological deficits, including sensorimotor paralysis of his right leg and deteriorating alertness. Due to the rapid course and rather late diagnosis of the infection, effective treatment could not be applied and he died 12 days after hospital admission. Conclusions: To the best of our knowledge, this is the second case of granulomatous acanthamoebic encephalitis reported within Germany. Our case highlights the importance of early diagnosis of granulomatous acanthamoebic encephalitis to prevent fatal outcome.

Original languageEnglish
Article number201
JournalJournal of Medical Case Reports
Volume12
Issue number1
DOIs
StatePublished - 12 Jul 2018

Keywords

  • Acanthamoeba species
  • GAE
  • HIV
  • Miltefosine treatment

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