Latest on enzymology of serotonin biosynthesis in walnut seeds

Peter Schröder, Claudia Abele, Petra Gohr, Uta Stuhlfauth-Roisch, Wolfgang Grosse

Research output: Contribution to journalArticlepeer-review

39 Scopus citations

Abstract

Serotonin (5-HT) accumulation in walnut cotyledons is seen as a detoxification mechanism protecting the sensitive plant tissues of seeds from highly toxic ammonia concentrations following seed desiccation. Different metabolic pathways and cell compartments are involved in biosynthesis and storage of 5-HT. Ammonia fixation and incorporation into the indole moiety of tryptophan is followed by 5-HT biosynthesis via tryptamine in a two-step pathway with the adaptive tryptophan decarboxylase and the constitutive tryptamine 5-hydroxylase. Evidence is provided that tryptamine 5-hydroxylase is a member of the cytochrome P450 family which is involved in lipid hydroxylation processes in the very early period of seed development.

Original languageEnglish
Pages (from-to)637-644
Number of pages8
JournalAdvances in Experimental Medicine and Biology
Volume467
StatePublished - 2000
Externally publishedYes

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