Language pathway tracking: Comparing nTMS-based DTI fiber tracking with a cubic ROIs-based protocol

Chiara Negwer, Nico Sollmann, Sebastian Ille, Theresa Hauck, Stefanie Maurer, Jan S. Kirschke, Florian Ringel, Bernhard Meyer, Sandro M. Krieg

Research output: Contribution to journalArticlepeer-review

39 Scopus citations

Abstract

OBJECTIVE: Diffusion tensor imaging (DTI) fiber tracking (FT) has been widely used in glioma surgery in recent years. It can provide helpful information about subcortical structures, especially in patients with eloquent space-occupying lesions. This study compared the newly developed navigated transcranial magnetic stimulation (nTMS)-based DTI FT of language pathways with the most reproducible protocol for language pathway tractography, using cubic regions of interest (ROIs) for the arcuate fascicle. METHODS: Thirty-seven patients with left-sided perisylvian lesions underwent language mapping by repetitive nTMS. DTI FT was performed using the cubic ROIs-based protocol and the authors' nTMS-based DTI FT approach. The same minimal fiber length and fractional anisotropy were chosen (50 mm and 0.2, respectively). Both protocols were performed with standard clinical tractography software. RESULTS: Both methods visualized language-related fiber tracts (i.e., corticonuclear tract, arcuate fascicle, uncinate fascicle, superior longitudinal fascicle, inferior longitudinal fascicle, arcuate fibers, commissural fibers, corticothalamic fibers, and frontooccipital fascicle) in all 37 patients. Using the cubic ROIs-based protocol, 39.9% of these languagerelated fiber tracts were detected in the examined patients, as opposed to 76.0% when performing nTMS-based DTI FT. For specifically tracking the arcuate fascicle, however, the cubic ROIs-based approach showed better results (97.3% vs 75.7% with nTMS-based DTI FT). CONCLUSIONS: The cubic ROIs-based protocol was designed for arcuate fascicle tractography, and this study shows that it is still useful for this intention. However, superior results were obtained using the nTMS-based DTI FT for visualization of other language-related fiber tracts.

Original languageEnglish
Pages (from-to)1006-1014
Number of pages9
JournalJournal of Neurosurgery
Volume126
Issue number3
DOIs
StatePublished - Mar 2017
Externally publishedYes

Keywords

  • Cortical mapping
  • Fiber tracking
  • Language
  • Navigated transcranial magnetic stimulation
  • Space-occupying lesions
  • Subcortical
  • Surgical technique

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