La remisión en la esquizofrenia: Validez, frecuencia, predictores y percepción de los pacientes después de cinco años

Translated title of the contribution: Remission in schizophrenia: Validity, frequency, predictors, and patients' perspective 5 years later

Martin Lambert, Anne Karow, Stefan Leucht, Benno G. Schimmelmann, Dieter Naber

Research output: Contribution to journalArticlepeer-review

159 Scopus citations

Abstract

In March 2005, the Remission in Schizophrenia Working Group (RSWG) proposed a consensus definition of symptomatic remission in schizophrenia and developed specific operational criteria for its assessment. They pointed out, however, that the validity and the relationship to other outcome dimensions required further examination. This article reviews studies on the validity, frequency, and predictors of symptomatic remission in schizophrenia and studies on patients' perspectives. These studies have demonstrated that the RSWG remission criteria appear achievable and sustainable for a significant proportion of patients, and are related to a better overall symptomatic status and functional outcome and, to a less clear extent, to a better quality of life and cognitive performance. However, achieving symptomatic remission is not automatically concurrent with an adequate status in other outcome dimensions. The results of the present review suggest that the RSWG remission criteria are valid and useful. As such, they should be consistently applied in clinical trials. However, the lack of consensus definitions of functional remission and adequate quality of life hampers research on their predictive validity on these outcome dimensions. Future research should therefore search for criteria of these dimensions and test whether the RSWG remission criteria consistently predict a "good" outcome with respect to functioning and quality of life.

Translated title of the contributionRemission in schizophrenia: Validity, frequency, predictors, and patients' perspective 5 years later
Original languageSpanish
Pages (from-to)393-407
Number of pages15
JournalDialogues in Clinical Neuroscience
Volume12
Issue number3
StatePublished - 2010

Keywords

  • Frequency
  • Predictor
  • Remission
  • Schizophrenia

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