Abstract
Pyruvate dehydrogenase complex-deficient strains of Corynebacterium glutamicum produce L- valine from glucose only after depletion of the acetate required for growth. Here we show that inactivation of the DeoR-type transcriptional regulator SugR or replacement of acetate by ethanol already in course of the growth phase results in efficient L-valine production.
Original language | English |
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Pages (from-to) | 1197-1200 |
Number of pages | 4 |
Journal | Applied and Environmental Microbiology |
Volume | 75 |
Issue number | 4 |
DOIs | |
State | Published - Feb 2009 |
Externally published | Yes |