L-valine production during growth of pyruvate dehydrogenase complex-deficient Corynebacterium glutamicum in the presence of ethanol or by inactivation of the transcriptional regulator SugR

Bastian Blombach, Annette Arndt, Marc Auchter, Bernhard J. Eikmanns

Research output: Contribution to journalArticlepeer-review

50 Scopus citations

Abstract

Pyruvate dehydrogenase complex-deficient strains of Corynebacterium glutamicum produce L- valine from glucose only after depletion of the acetate required for growth. Here we show that inactivation of the DeoR-type transcriptional regulator SugR or replacement of acetate by ethanol already in course of the growth phase results in efficient L-valine production.

Original languageEnglish
Pages (from-to)1197-1200
Number of pages4
JournalApplied and Environmental Microbiology
Volume75
Issue number4
DOIs
StatePublished - Feb 2009
Externally publishedYes

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