Abstract
Over the last decade, the development of single molecule methods has allowed us to interface individual biomolecules, to subject them to mechanical load and to measure their conformational response. In this article, we introduce the new possibilities of force spectroscopy by AFM (atomic force microscope) and optical tweezers for the study of proteins. Applications of force spectroscopy for protein folding as well as force-dependent ligand binding in cell adhesion are discussed.
Translated title of the contribution | Single molecule analysis: Force spectroscopy - Dynamics and manipulation of single molecules |
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Original language | German |
Pages (from-to) | 33-35 |
Number of pages | 3 |
Journal | BioSpektrum |
Volume | 20 |
Issue number | 1 |
DOIs | |
State | Published - Feb 2014 |