Abstract
In necrotizing pancreatitis, bacterial contamination of the necrosis with enteric germs impaires the patient's prognosis. It is unclear, whether antibiotic prophylaxis has a positive effect in those patients. Up to now, only few data exist with regard to the pharmacokinetics of broad-spectrum antibiotics in human pancreatic tissue, which could serve as basis for the evaluatiuon of an appropriate antibiotic regimen. In our study, we focused on the concentrations of Cefotiam, a broad-spectrum cephalosporin, in human pancreatic tissue, 14 patients undergoing pancreatic resection received 2 g Cefotiam as bolus infusion, Cefotiam concentrations were measured in pancreatic tissue and serum by HPLC. We found a mean pancreatic tissue concentration of 9.1 mg/kg. With reference to the minimal inhibitory concentrations of the relevant bacteria found in pancreatic infection, cefotiam seems to be an appropriate drug for the treatment of septic complications in necrotizing pancreatitis.
| Translated title of the contribution | Concentrations of cefotiam in human pancreatic tissues |
|---|---|
| Original language | German |
| Pages (from-to) | 225-228 |
| Number of pages | 4 |
| Journal | Antiinfective Drugs and Chemotherapy |
| Volume | 13 |
| Issue number | 4 |
| State | Published - 1995 |
| Externally published | Yes |