Abstract
Chemical modification of standard gammaglobulin with enzyme treatment (pepsin) or stabilization (ß-propiolactone) is able to influence elimination, fragmentation and organ distribution of intravenously administered gammaglobulins as shown in 36 dogs after i.v. application of allogenic and xenogenic gammaglobulin preparations. Pepsin-gammaglobulin was eliminated and fragmented most rapidly. Gammaglobulin concentrations of all preparations in the skin showed as slower decrease than comparable blood concentrations. The highest skin concentrations 10 days after i.v. application were found for β-propiolactone gammaglobulin with 6.2 ± 1.6 μg/g compared to a blood level of 7.9 ±0.9 μg/ml.
| Translated title of the contribution | Concentration of intravenously administered gammaglobulin preparations in dog skin |
|---|---|
| Original language | German |
| Pages (from-to) | 201-206 |
| Number of pages | 6 |
| Journal | Archives of Dermatological Research |
| Volume | 260 |
| Issue number | 3 |
| DOIs | |
| State | Published - Jan 1977 |
| Externally published | Yes |