Kombination von Brachytherapie und Chirurgie bei Tumoren mit Orbita-/Schädelbasisinfiltration

Translated title of the contribution: Brachytherapy in combination with function-preserving surgery of cancer of the paranasal sinus

J. E. Meyer, C. Brocks, P. Lamcke, R. J. Strege, S. Maune, H. M. Mehdorn, B. Wollenberg, G. Kovacs

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Brachytherapy in Combination with Function-Preserving Surgery of Cancer of the Paranasal Sinus Backgrund: Prognosis of patients with advanced/recurrent cancer of paranasal sinuses and orbit with infiltration of the skull base is very bad. Radical surgery does not improve prognosis. A disadvantage of the radical surgery is the functional loss and the residual cosmetic defect. We present the results of a function-preserving surgery in combination with interstitial, image adapted brachytherapy (IABT) for the treatment of these cancers. Methods and Patients: Ten patients with paranasal sinus cancer and 16 patients with sarcomas (n=26) were retrospectively analysed. After a maximum tumor resection (mostly R1R2 resections), 212 flexible afterloading plastic tubes were implanted. The postoperative IABT total dose was 1025 Gy in 2.5 Gy fractions twice daily fractions for 5 days. Results: In all cases the eye was obtained without functional damage. The IABT was well tolerated. The visual and cosmetic results were satisfactory. Postoperative complications occurred in 7 out of 26 cases without a serious long-term adverse event. Significant radiation-induced complications were found in patients with orbital or skull base involvement. The three years overall survival was 60% for rhabdomyosarcoma, and 33% for the paranasal sinus cancers. Conclusions: These results show that a combined treatment of function-preserving surgery and a IABT is a feasible, successful and well-tolerated option for curative, salvage and palliative therapy for selected patients with advanced or recurrent carcinoma of the paranasal sinuses and orbit.

Translated title of the contributionBrachytherapy in combination with function-preserving surgery of cancer of the paranasal sinus
Original languageGerman
Pages (from-to)358-366
Number of pages9
JournalLaryngo- Rhino- Otologie
Issue number6
StatePublished - 2010
Externally publishedYes


Dive into the research topics of 'Brachytherapy in combination with function-preserving surgery of cancer of the paranasal sinus'. Together they form a unique fingerprint.

Cite this