Klinische effekte der allergenreduktion durch encasing - Eine metaanalyse

Background: The clinical effect of encasing for the reduction of house dust mite allergens was determined using a meta-analysis of randomized, prospective and controlled surveys. Methods: The literature search was conducted via "Medline" and the Cochrane Centre. The parameters FEV₁, PEF, BHR, symptom score, drug consumption and allergen reduction were used as criteria for clinical improvement. The appropriate p values were quoted as results. Results: Twelve of the 93 surveys determined complied with the criteria specified. The comparison between the intervention and the control group showed a significant improvement in the parameters BHR (p = 0.04), symptom score (p = 0.0007), drug consumption (p = 0.043) and allergen reduction (p < 0.0001). The surveys were grouped according to the type of encasing used. The first group (Allergy Control) showed significant improvements for the parameters PEF (p = 0.02), BHR (p = 0.037) and allergen reduction (p = 0.03). In the second group (Intervent), significant improvements were noted for the parameters symptom score (p = 0.016), drug consumption (p = 0.02) and allergen reduction (p < 0.0001). The third group, which included various encasement types, showed significant improvements for the parameters symptom score (p = 0.011) and allergen reduction (p = 0.0001). Conclusion: Thus, we have shown that the encasing method significantly reduces allergens and leads to measurable clinical effects.