Kinetic accessibility of buried DNA sites in nucleosomes

Wolfram Möbius, Richard A. Neher, Ulrich Gerland

Research output: Contribution to journalArticlepeer-review

33 Scopus citations

Abstract

Using a theoretical model for spontaneous partial DNA unwrapping from histones, we study the transient exposure of protein-binding DNA sites within nucleosomes. We focus on the functional dependence of the rates for site exposure and reburial on the site position, which is measurable experimentally and pertinent to gene regulation. We find the dependence to be roughly described by a random walker model. Close inspection reveals a surprising physical effect of flexibility-assisted barrier crossing, which we characterize within a toy model, the "semiflexible Brownian rotor."

Original languageEnglish
Article number208102
JournalPhysical Review Letters
Volume97
Issue number20
DOIs
StatePublished - 2006
Externally publishedYes

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