Kidney transplantation following treatment with cyclophosphamide and bone marrow grafting.

J. von Scheel, H. J. Kolb, K. H. Duswald, I. Rieder, C. Chaussy, H. Grosse-Wilde, S. Scholz, K. Pielsticker

Research output: Contribution to journalArticlepeer-review

Abstract

Canine cyclophosphamide (CY) chimeras permanently accept kidney and skin grafts as do radiation chimeras. Three of five dogs with reversion of chimerism rejected their kidney grafts within 11-16 days, while two of them retained their kidney grafts permanently. These results suggest that the reversion of chimerism in CY chimeras may be due to different mechanisms, either immunologic rejection or a nonimmunologic substitution of the grafted marrow by the host's own hemopoiesis.

Original languageEnglish
Pages (from-to)261-263
Number of pages3
JournalTransplantation Proceedings
Volume9
Issue number1
StatePublished - Mar 1977
Externally publishedYes

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