Key Determinants of Rab Specificity

Aymelt Itzen; Roger S. Goody

doi:10.1016/j.str.2008.09.002

Key Determinants of Rab Specificity

Aymelt Itzen, Roger S. Goody

Max Planck Inst. fur Molec. Physiol.

Research output: Contribution to journal › Short survey › peer-review

10 Scopus citations

Abstract

Structures are reported for complexes between Rab27 and the Rab27-binding domains of two molecules involved in successive steps in melanosome transport. Comparison of the Rab27B:Slac2-a (Chavas et al., 2008) and Rab27A:Slp2-a (Kukimoto-Niino et al., 2008) structures with that of the Rab3A:Rabphilin complex gives important clues to the specificity of the interactions.

Original language	English
Pages (from-to)	1437-1439
Number of pages	3
Journal	Structure
Volume	16
Issue number	10
DOIs	https://doi.org/10.1016/j.str.2008.09.002
State	Published - 8 Oct 2008
Externally published	Yes

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10.1016/j.str.2008.09.002

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title = "Key Determinants of Rab Specificity",

abstract = "Structures are reported for complexes between Rab27 and the Rab27-binding domains of two molecules involved in successive steps in melanosome transport. Comparison of the Rab27B:Slac2-a (Chavas et al., 2008) and Rab27A:Slp2-a (Kukimoto-Niino et al., 2008) structures with that of the Rab3A:Rabphilin complex gives important clues to the specificity of the interactions.",

author = "Aymelt Itzen and Goody, {Roger S.}",

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AU - Itzen, Aymelt

AU - Goody, Roger S.

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N2 - Structures are reported for complexes between Rab27 and the Rab27-binding domains of two molecules involved in successive steps in melanosome transport. Comparison of the Rab27B:Slac2-a (Chavas et al., 2008) and Rab27A:Slp2-a (Kukimoto-Niino et al., 2008) structures with that of the Rab3A:Rabphilin complex gives important clues to the specificity of the interactions.

AB - Structures are reported for complexes between Rab27 and the Rab27-binding domains of two molecules involved in successive steps in melanosome transport. Comparison of the Rab27B:Slac2-a (Chavas et al., 2008) and Rab27A:Slp2-a (Kukimoto-Niino et al., 2008) structures with that of the Rab3A:Rabphilin complex gives important clues to the specificity of the interactions.

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U2 - 10.1016/j.str.2008.09.002

DO - 10.1016/j.str.2008.09.002

M3 - Short survey

C2 - 18940598

AN - SCOPUS:53049102642

SN - 0969-2126

VL - 16

SP - 1437

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JO - Structure

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Key Determinants of Rab Specificity

Abstract

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