TY - JOUR
T1 - Keine assoziation zwischen p53-uberexpression und polarographisch gemessener tumoroxygenierung bei patienten mit kopf-hals-karzinomen
AU - Becker, Axel
AU - Stadler, Peter
AU - Krause, Ulf
AU - Kuhnt, Thomas
AU - Hänsgen, Gabriele
AU - Dettmar, Peer
AU - Feldmann, Horst Jürgen
AU - Rath, Friedrich Wilhelm
AU - Molls, Michael
AU - Dunst, Jürgen
PY - 2000
Y1 - 2000
N2 - Purpose: Clinical investigation Of a potential relationship between the polarographically measured tumor oxygenation and the p53 status in patients with squamous cell carcinoma of the head and neck. Patients and Methods: In 99 patients with mostly advanced, histologically proven squamous cell carcinoma of the head and neck we estimated the classical tumor parameters (TNM stage, histological grading) the immunohistochemical p53-overexpression (DO-7) and the tumor oxygenation status (Eppendorf pO2 Histograph). The tumor volume and the hemoglobin concentration were evaluated simultaneously. Results: No statistically significant difference could be detected between immunohistological p53-positive (p53 ≥ 10% stained cells) and p53-negative tumors (p53 < 10% stained cells) regarding both the median pO2 and the relative frequency of values ≤5 mm Hg. Moreover, no statistically relevant differences could be seen between both p53-groups considering the hemoglobin concentration, the TNM stage, the histological grading and the tumor volume. Conclusion: Our data imply that there is no association between p53-overexpression and tumor hypoxia in head and neck carcinomas. However, this is not necessarily in contradiction to experimental or clinical data that confirmed a relationship between hypoxia and p53-mediated increased malignancy of tumor cells in other tumor entities. The comparable oxygenation status of p53-positive and p53-negative tumors in our study is associated with an analogous clinical tumor aggressiveness of both groups. That could be caused by a hypoxia related but p53-independent selection of tumor cells with a more malignant phenotype in head and neck carcinomas. However, further research is needed to prove this possible relationship.
AB - Purpose: Clinical investigation Of a potential relationship between the polarographically measured tumor oxygenation and the p53 status in patients with squamous cell carcinoma of the head and neck. Patients and Methods: In 99 patients with mostly advanced, histologically proven squamous cell carcinoma of the head and neck we estimated the classical tumor parameters (TNM stage, histological grading) the immunohistochemical p53-overexpression (DO-7) and the tumor oxygenation status (Eppendorf pO2 Histograph). The tumor volume and the hemoglobin concentration were evaluated simultaneously. Results: No statistically significant difference could be detected between immunohistological p53-positive (p53 ≥ 10% stained cells) and p53-negative tumors (p53 < 10% stained cells) regarding both the median pO2 and the relative frequency of values ≤5 mm Hg. Moreover, no statistically relevant differences could be seen between both p53-groups considering the hemoglobin concentration, the TNM stage, the histological grading and the tumor volume. Conclusion: Our data imply that there is no association between p53-overexpression and tumor hypoxia in head and neck carcinomas. However, this is not necessarily in contradiction to experimental or clinical data that confirmed a relationship between hypoxia and p53-mediated increased malignancy of tumor cells in other tumor entities. The comparable oxygenation status of p53-positive and p53-negative tumors in our study is associated with an analogous clinical tumor aggressiveness of both groups. That could be caused by a hypoxia related but p53-independent selection of tumor cells with a more malignant phenotype in head and neck carcinomas. However, further research is needed to prove this possible relationship.
KW - Head and neck carcinomas
KW - Hypoxia
KW - p53
UR - http://www.scopus.com/inward/record.url?scp=0033809497&partnerID=8YFLogxK
U2 - 10.1007/pl00002314
DO - 10.1007/pl00002314
M3 - Artikel
C2 - 11068594
AN - SCOPUS:0033809497
SN - 0179-7158
VL - 176
SP - 475
EP - 480
JO - Strahlentherapie und Onkologie
JF - Strahlentherapie und Onkologie
IS - 10
ER -