TY - JOUR
T1 - Joint and tendon involvement predict disease progression in systemic sclerosis
T2 - A EUSTAR prospective study
AU - EUSTAR Collaborators
AU - Avouac, Jérôme
AU - Walker, Ulrich A.
AU - Hachulla, Eric
AU - Riemekasten, Gabriela
AU - Cuomo, Giovanna
AU - Carreira, Patricia E.
AU - Caramaschi, Paola
AU - Ananieva, Lidia P.
AU - Matucci-Cerinic, Marco
AU - Czirjak, Laszlo
AU - Denton, Christopher
AU - Ladner, Ulf Müller
AU - Allanore, Yannick
AU - Guiducci, Serena
AU - Tyndall, Alan
AU - Lapadula, Giovanni
AU - Iannone, Florenzo
AU - Distler, Oliver
AU - Becvar, Radim
AU - Sierakowsky, Stanislaw
AU - Bielecka, Otylia Kowal
AU - Cutolo, Maurizio
AU - Sulli, Alberto
AU - Valentini, Gabriele
AU - Rednic, Simona
AU - Nicoara, Ileana
AU - Vlachoyiannopoulos, Panayiotis G.
AU - Montecucco, Carlomaurizio
AU - Caporali, Roberto
AU - Novak, Srdan
AU - Chizzolini, Carlo
AU - Kucharz, Eugene J.
AU - Kotulska, Anna
AU - Cozzi, Franco
AU - Rozman, Blaz
AU - Mallia, Carmel
AU - Coleiro, Bernard
AU - Gabrielli, Armando
AU - Farge-Bancel, Dominique
AU - Hadj-Khelifa, Sondess
AU - Airò, Paolo
AU - Hesselstrand, Roger
AU - Scheja, Agneta
AU - Martinovic, Duska
AU - Gurman, Alexandra Balbir
AU - Braun-Moscovici, Yolanda
AU - Hunzelmann, Nicolas
AU - Pellerito, Raffaele
AU - Bambara, Lisa Maria
AU - Eyerich, Kilian
PY - 2016/1/1
Y1 - 2016/1/1
N2 - Objective: To determine whether joint synovitis and tendon friction rubs (TFRs) can predict the progression of systemic sclerosis (SSc) over time. Patients and methods We performed a prospective cohort study that included 1301 patients with SSc from the EUSTAR database with disease duration ≤3 years at inclusion and with a follow-up of at least 2 years. Presence or absence at clinical examination of synovitis and TFRs was extracted at baseline. Outcomes were skin, cardiovascular, renal and lung progression. Overall disease progression was defined according to the occurrence of at least one organ progression. Results: Joint synovitis (HR: 1.26, 95% CI 1.01 to 1.59) and TFRs (HR: 1.32, 95% CI 1.03 to 1.70) were independently predictive of overall disease progression, as were also the diffuse cutaneous subset (HR: 1.30, 95% CI 1.05 to 1.61) and positive antitopoisomerase-I antibodies (HR: 1.25, 95% CI 1.02 to 1.53). Regarding skin progression, joint synovitis (HR: 1.67, 95% CI 1.06 to 2.64) and TFRs (HR: 1.69, 95% CI 1.02 to 2.77) were also independently predictive of worsening of the modified Rodnan skin score. For cardiovascular progression, joint synovitis was predictive of the occurrence of new digital ulcer(s) (HR: 1.45, 95% CI 1.08 to 1.96) and decreased left ventricular ejection fraction (HR: 2.20, 95% CI 1.06 to 4.57); TFRs were confirmed to be an independent predictor of scleroderma renal crisis (HR: 2.33, 95% CI 1.03 to 6.19). Conclusions: Joint synovitis and TFRs are independent predictive factors for disease progression in patients with early SSc. These easily detected clinical markers may be useful for the risk stratification of patients with SSc.
AB - Objective: To determine whether joint synovitis and tendon friction rubs (TFRs) can predict the progression of systemic sclerosis (SSc) over time. Patients and methods We performed a prospective cohort study that included 1301 patients with SSc from the EUSTAR database with disease duration ≤3 years at inclusion and with a follow-up of at least 2 years. Presence or absence at clinical examination of synovitis and TFRs was extracted at baseline. Outcomes were skin, cardiovascular, renal and lung progression. Overall disease progression was defined according to the occurrence of at least one organ progression. Results: Joint synovitis (HR: 1.26, 95% CI 1.01 to 1.59) and TFRs (HR: 1.32, 95% CI 1.03 to 1.70) were independently predictive of overall disease progression, as were also the diffuse cutaneous subset (HR: 1.30, 95% CI 1.05 to 1.61) and positive antitopoisomerase-I antibodies (HR: 1.25, 95% CI 1.02 to 1.53). Regarding skin progression, joint synovitis (HR: 1.67, 95% CI 1.06 to 2.64) and TFRs (HR: 1.69, 95% CI 1.02 to 2.77) were also independently predictive of worsening of the modified Rodnan skin score. For cardiovascular progression, joint synovitis was predictive of the occurrence of new digital ulcer(s) (HR: 1.45, 95% CI 1.08 to 1.96) and decreased left ventricular ejection fraction (HR: 2.20, 95% CI 1.06 to 4.57); TFRs were confirmed to be an independent predictor of scleroderma renal crisis (HR: 2.33, 95% CI 1.03 to 6.19). Conclusions: Joint synovitis and TFRs are independent predictive factors for disease progression in patients with early SSc. These easily detected clinical markers may be useful for the risk stratification of patients with SSc.
UR - http://www.scopus.com/inward/record.url?scp=84954441382&partnerID=8YFLogxK
U2 - 10.1136/annrheumdis-2014-205295
DO - 10.1136/annrheumdis-2014-205295
M3 - Article
C2 - 25165035
AN - SCOPUS:84954441382
SN - 0003-4967
VL - 75
SP - 103
EP - 109
JO - Annals of the Rheumatic Diseases
JF - Annals of the Rheumatic Diseases
IS - 1
ER -