Itch and eczema

Ulf Darsow, Florian Pfab, Michael Valet, Thomas R. Tlle, Johannes Ring

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

9 Scopus citations


Eczema/dermatitis belongs to the most pruritic of skin diseases. Pruritogenic mediators in the skin are still mostly unknown. Recent studies, however, have shown that the histamine 4 receptor plays an important role in itch pathophysiology; tryptase and IL-31 are also involved in atopic eczema itch. Differences in itch perception and itch kinetics between healthy volunteers and eczema patients point towards ongoing central nervous inhibitory activity in patients. Questionnaire studies reported comparatively higher loads in affective items chosen by patients with atopic eczema. In the concept of eczema patient management, the therapy of clinical pruritus has to consider pathophysiology and perception by combining topical and systemic treatment.

Original languageEnglish
Title of host publicationNew Trends in Allergy and Atopic Eczema
EditorsJohannes Ring, Heidrun Behrendt, Ulf Darsow
Number of pages8
StatePublished - Mar 2012
Externally publishedYes

Publication series

NameChemical Immunology and Allergy
ISSN (Print)1660-2242
ISSN (Electronic)1662-2898


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