Isoelectric focusing with immobilized pH gradients for the analysis of transferrin (Tf) subtypes and variants

Angelika Görg; J. Weser; R. Westermeier; W. Postel; S. Weidinger; W. Patutschnick; H. Cleve

doi:10.1007/BF00279397

Isoelectric focusing with immobilized pH gradients for the analysis of transferrin (Tf) subtypes and variants

Angelika Görg
, J. Weser
, R. Westermeier
, W. Postel
, S. Weidinger
, W. Patutschnick
, H. Cleve

TUM Emeriti of Excellence

Research output: Contribution to journal › Article › peer-review

50 Scopus citations

Abstract

The human serum transferrin (Tf) system was analyzed by isoelectric focusing (IEF) with immobilized pH gradients. For the demonstration of the genetic variability the Fe₁-Tf region was chosen. The pH range suitable for analysis of the Tf system was pH 5.20 to pH 5.75. The phenotypes of the common six TfC subtypes are described. No further heterogeneity among TfC1, TfC2, and TfC3 was noted. Also presented are the phenotypes of the TfC6 subtype, and of three different TfB and three different TfD variants. IEF with immobilized pH gradients appears to be a suitable method for the analysis of the inherited transferrin polymorphism.

Original language	English
Pages (from-to)	222-226
Number of pages	5
Journal	Human Genetics
Volume	64
Issue number	3
DOIs	https://doi.org/10.1007/BF00279397
State	Published - Sep 1983

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title = "Isoelectric focusing with immobilized pH gradients for the analysis of transferrin (Tf) subtypes and variants",

abstract = "The human serum transferrin (Tf) system was analyzed by isoelectric focusing (IEF) with immobilized pH gradients. For the demonstration of the genetic variability the Fe1-Tf region was chosen. The pH range suitable for analysis of the Tf system was pH 5.20 to pH 5.75. The phenotypes of the common six TfC subtypes are described. No further heterogeneity among TfC1, TfC2, and TfC3 was noted. Also presented are the phenotypes of the TfC6 subtype, and of three different TfB and three different TfD variants. IEF with immobilized pH gradients appears to be a suitable method for the analysis of the inherited transferrin polymorphism.",

author = "Angelika G{\"o}rg and J. Weser and R. Westermeier and W. Postel and S. Weidinger and W. Patutschnick and H. Cleve",

year = "1983",

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doi = "10.1007/BF00279397",

language = "English",

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T1 - Isoelectric focusing with immobilized pH gradients for the analysis of transferrin (Tf) subtypes and variants

AU - Görg, Angelika

AU - Weser, J.

AU - Westermeier, R.

AU - Postel, W.

AU - Weidinger, S.

AU - Patutschnick, W.

AU - Cleve, H.

PY - 1983/9

Y1 - 1983/9

N2 - The human serum transferrin (Tf) system was analyzed by isoelectric focusing (IEF) with immobilized pH gradients. For the demonstration of the genetic variability the Fe1-Tf region was chosen. The pH range suitable for analysis of the Tf system was pH 5.20 to pH 5.75. The phenotypes of the common six TfC subtypes are described. No further heterogeneity among TfC1, TfC2, and TfC3 was noted. Also presented are the phenotypes of the TfC6 subtype, and of three different TfB and three different TfD variants. IEF with immobilized pH gradients appears to be a suitable method for the analysis of the inherited transferrin polymorphism.

AB - The human serum transferrin (Tf) system was analyzed by isoelectric focusing (IEF) with immobilized pH gradients. For the demonstration of the genetic variability the Fe1-Tf region was chosen. The pH range suitable for analysis of the Tf system was pH 5.20 to pH 5.75. The phenotypes of the common six TfC subtypes are described. No further heterogeneity among TfC1, TfC2, and TfC3 was noted. Also presented are the phenotypes of the TfC6 subtype, and of three different TfB and three different TfD variants. IEF with immobilized pH gradients appears to be a suitable method for the analysis of the inherited transferrin polymorphism.

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DO - 10.1007/BF00279397

M3 - Article

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AN - SCOPUS:0020595397

SN - 0340-6717

VL - 64

SP - 222

EP - 226

JO - Human Genetics

JF - Human Genetics

IS - 3

ER -

Isoelectric focusing with immobilized pH gradients for the analysis of transferrin (Tf) subtypes and variants

Abstract

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