Islet1 cardiovascular progenitors: A single source for heart lineages?

Karl Ludwig Laugwitz, Alessandra Moretti, Leslie Caron, Atsushi Nakano, Kenneth R. Chien

Research output: Contribution to journalReview articlepeer-review

205 Scopus citations


The creation of regenerative stem cell therapies for heart disease requires that we understand the molecular mechanisms that govern the fates and differentiation of the diverse muscle and non-muscle cell lineages of the heart. Recently, different cardiac cell types have been reported to arise from a common, multipotent Islet1 (lsl1)-positive progenitor, suggesting that a clonal model of heart lineage diversification might occur that is analogous to hematopoiesis. The ability to isolate, renew and differentiate lsl1+ precursors from postnatal and embryonic hearts and from embryonic stem cells provides a powerful cell-based system for characterizing the signaling pathways that control cardiovascular progenitor formation, renewal, lineage specification and conversion to specific differentiated progeny.

Original languageEnglish
Pages (from-to)193-205
Number of pages13
JournalDevelopment (Cambridge)
Issue number2
StatePublished - Jan 2008
Externally publishedYes


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