Abstract
The pathogenesis of ischemia/reperfusion injury (I/R) after kidney transplantation is complex. The I/R damage belongs to the factors that can influence the development of chronic allograft nephropathy (CAN), one of the leading causes of late allograft loss. The prevention of I/R could therefore potentially reduce the development or progression of CAN. During recent years animal experiments contributed to our knowledge of I/R and give hope for new therapeutic strategies. The present evidence-based therapy has not changed considerably in the last few years. Based on the pathophysiology of I/R we want to discuss methods to influence I/R. by established concepts of organ preservation and give an outlook on new therapeutic approaches.
| Translated title of the contribution | Ischemia-reperfusion injury after kidney transplantation |
|---|---|
| Original language | German |
| Pages (from-to) | 15-25 |
| Number of pages | 11 |
| Journal | TransplantLinc |
| Issue number | 10 |
| State | Published - 2005 |