Irradiation for conjunctival granulocytic sarcoma

Katharina Fleckenstein, Hans Geinitz, Anca Grosu, Katharina Goetze, Martin Werner, Michael Molls

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

Case History and Findings: A 73-year-old woman with a history of myeloproliferative syndrome (MPS) presented with bilateral chemosis, redness and burning of the eyes. The ocular motility was severely impaired. Ophthalmological examination revealed markedly distended conjunctivas on both sides. Biopsy disclosed conjunctival granulocytic sarcoma as an initial symptom of acute myelogenous leukemia (AML). Diagnosis was confirmed by peripheral blood smear and bone marrow aspiration. Treatment and Outcome: The orbital tumor disappeared completely after local external beam irradiation with a total dose of 30 Gy and no further orbital recurrence occurred. With chemotherapy following irradiation transient hematological remission was achieved. 5 months after diagnosis the patient died of respiratory failure following atypical pneumonia as a consequence of her underlying disorder. Conclusion: Detection of orbital granulocytic sarcoma, even in the absence of typical leukemic symptoms is of practical importance, because treatment with irradiation can lead to stabilization or improvement in the patient's vision.

Original languageEnglish
Pages (from-to)187-190
Number of pages4
JournalStrahlentherapie und Onkologie
Volume179
Issue number3
DOIs
StatePublished - 1 Mar 2003

Keywords

  • Conjunctiva
  • Granulocytic sarcoma
  • Radiotherapy

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