Iron-catalyzed hydrogenation for the in situ regeneration of an NAD(P)H model: Biomimetic reduction of α-Keto-/α-iminoesters

Liang Qiu Lu, Yuehui Li, Kathrin Junge, Matthias Beller

Research output: Contribution to journalArticlepeer-review

80 Scopus citations

Abstract

Two irons for a smoother finish: An NAD(P)H model was regenerated readily in situ by iron-catalyzed reduction with molecular hydrogen. The subsequent biomimetic reduction of α-keto-/ α-iminoesters proceeded smoothly in the presence of an iron-based Lewis acid (LA) to provide α-hydroxyesters and amino acid esters in good to excellent yields (see scheme; NAD(P) +=nicotinamide adenine dinucleotide (phosphate), TM=transition metal).

Original languageEnglish
Pages (from-to)8382-8386
Number of pages5
JournalAngewandte Chemie International Edition in English
Volume52
Issue number32
DOIs
StatePublished - 5 Aug 2013
Externally publishedYes

Keywords

  • biomimetic reduction
  • hydrogenation
  • iminoesters
  • iron catalysis
  • α-ketoesters

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