Iron-catalyzed enantioselective hydrosilylation of ketones

Nadim S. Shaikh, Stephan Enthaler, Kathrin Junge, Matthias Beller

Research output: Contribution to journalArticlepeer-review

233 Scopus citations

Abstract

(Chemical Equation Presented) Reductions under iron rule: Enantioselective hydrosilylation of prochiral ketones with inexpensive and environmentally benign iron catalysts proceed smoothly in the presence of (S,S)-Me-duphos (see scheme; (S,S)-Me-duphos=1,2-(bis-[(2S,5S)]-2,5-dimethylphospholano)benzene). A broad range of aryl ketones is converted into the corresponding secondary alcohols in up to 99% enantioselectivity and quantitative yields.

Original languageEnglish
Pages (from-to)2497-2501
Number of pages5
JournalAngewandte Chemie International Edition in English
Volume47
Issue number13
DOIs
StatePublished - 14 Mar 2008
Externally publishedYes

Keywords

  • Alcohols
  • Asymmetric catalysis
  • Homogeneous catalysis
  • Hydrosilylation
  • Iron

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