Abstract
Serotonin is regarded as an essential neurotransmitter in thermoregulation. We evaluated the influence of the serotonergic antagonist dolasetron on thermoregulation and postanaesthetic shivering in mildly hypothermic patients in a randomised placebo-controlled study. The incidence of shivering was 24% after dolasetron compared to 69% after placebo (p<0.01). During the first 80 min postoperatively, core temperature remained lower in the treatment group (p<0.05). After dolasetron, 20% of the patients experienced thermal discomfort compared to 54% after placebo (p<0.05). Serotonin antagonism seems to lower the human thermal set-range thereby reducing metabolic cold defence and discomfort associated with postoperative hypothermia.
Original language | English |
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Pages (from-to) | 159-166 |
Number of pages | 8 |
Journal | Journal of Thermal Biology |
Volume | 27 |
Issue number | 2 |
DOIs | |
State | Published - 2002 |
Externally published | Yes |
Keywords
- Anaesthesia
- Cold challenge
- Dolasetron
- Human
- Neurotransmitter
- Serotonin
- Set-range
- Shivering
- Thermoregulation