Investigating altered brain development in infants with congenital heart disease using tensor-based morphometry

Isabel H.X. Ng; Alexandra F. Bonthrone; Christopher J. Kelly; Lucilio Cordero-Grande; Emer J. Hughes; Anthony N. Price; Jana Hutter; Suresh Victor; Andreas Schuh; Daniel Rueckert; Joseph V. Hajnal; John Simpson; A. David Edwards; Mary A. Rutherford; Dafnis Batalle; Serena J. Counsell

doi:10.1038/s41598-020-72009-3

Investigating altered brain development in infants with congenital heart disease using tensor-based morphometry

Isabel H.X. Ng, Alexandra F. Bonthrone, Christopher J. Kelly, Lucilio Cordero-Grande, Emer J. Hughes, Anthony N. Price, Jana Hutter, Suresh Victor, Andreas Schuh, Daniel Rueckert, Joseph V. Hajnal, John Simpson, A. David Edwards, Mary A. Rutherford, Dafnis Batalle, Serena J. Counsell

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Abstract

Magnetic resonance (MR) imaging studies have demonstrated reduced global and regional brain volumes in infants with congenital heart disease (CHD). This study aimed to provide a more detailed evaluation of altered structural brain development in newborn infants with CHD compared to healthy controls using tensor-based morphometry (TBM). We compared brain development in 64 infants with CHD to 192 age- and sex-matched healthy controls. T2-weighted MR images obtained prior to surgery were analysed to compare voxel-wise differences in structure across the whole brain between groups. Cerebral oxygen delivery (CDO₂) was measured in infants with CHD (n = 49) using phase contrast MR imaging and the relationship between CDO₂ and voxel-wise brain structure was assessed using TBM. After correcting for global scaling differences, clusters of significant volume reduction in infants with CHD were demonstrated bilaterally within the basal ganglia, thalami, corpus callosum, occipital, temporal, parietal and frontal lobes, and right hippocampus (p < 0.025 after family-wise error correction). Clusters of significant volume expansion in infants with CHD were identified in cerebrospinal fluid spaces (p < 0.025). After correcting for global brain size, there was no significant association between voxel-wise brain structure and CDO₂. This study localizes abnormal brain development in infants with CHD, identifying areas of particular vulnerability.

Original language	English
Article number	14909
Journal	Scientific Reports
Volume	10
Issue number	1
DOIs	https://doi.org/10.1038/s41598-020-72009-3
State	Published - 1 Dec 2020
Externally published	Yes

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Ng, I. H. X., Bonthrone, A. F., Kelly, C. J., Cordero-Grande, L., Hughes, E. J., Price, A. N., Hutter, J., Victor, S., Schuh, A., Rueckert, D., Hajnal, J. V., Simpson, J., Edwards, A. D., Rutherford, M. A., Batalle, D., & Counsell, S. J. (2020). Investigating altered brain development in infants with congenital heart disease using tensor-based morphometry. Scientific Reports, 10(1), Article 14909. https://doi.org/10.1038/s41598-020-72009-3

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title = "Investigating altered brain development in infants with congenital heart disease using tensor-based morphometry",

abstract = "Magnetic resonance (MR) imaging studies have demonstrated reduced global and regional brain volumes in infants with congenital heart disease (CHD). This study aimed to provide a more detailed evaluation of altered structural brain development in newborn infants with CHD compared to healthy controls using tensor-based morphometry (TBM). We compared brain development in 64 infants with CHD to 192 age- and sex-matched healthy controls. T2-weighted MR images obtained prior to surgery were analysed to compare voxel-wise differences in structure across the whole brain between groups. Cerebral oxygen delivery (CDO2) was measured in infants with CHD (n = 49) using phase contrast MR imaging and the relationship between CDO2 and voxel-wise brain structure was assessed using TBM. After correcting for global scaling differences, clusters of significant volume reduction in infants with CHD were demonstrated bilaterally within the basal ganglia, thalami, corpus callosum, occipital, temporal, parietal and frontal lobes, and right hippocampus (p < 0.025 after family-wise error correction). Clusters of significant volume expansion in infants with CHD were identified in cerebrospinal fluid spaces (p < 0.025). After correcting for global brain size, there was no significant association between voxel-wise brain structure and CDO2. This study localizes abnormal brain development in infants with CHD, identifying areas of particular vulnerability.",

author = "Ng, {Isabel H.X.} and Bonthrone, {Alexandra F.} and Kelly, {Christopher J.} and Lucilio Cordero-Grande and Hughes, {Emer J.} and Price, {Anthony N.} and Jana Hutter and Suresh Victor and Andreas Schuh and Daniel Rueckert and Hajnal, {Joseph V.} and John Simpson and Edwards, {A. David} and Rutherford, {Mary A.} and Dafnis Batalle and Counsell, {Serena J.}",

note = "Publisher Copyright: {\textcopyright} 2020, The Author(s).",

year = "2020",

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doi = "10.1038/s41598-020-72009-3",

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Ng, IHX, Bonthrone, AF, Kelly, CJ, Cordero-Grande, L, Hughes, EJ, Price, AN, Hutter, J, Victor, S, Schuh, A, Rueckert, D, Hajnal, JV, Simpson, J, Edwards, AD, Rutherford, MA, Batalle, D & Counsell, SJ 2020, 'Investigating altered brain development in infants with congenital heart disease using tensor-based morphometry', Scientific Reports, vol. 10, no. 1, 14909. https://doi.org/10.1038/s41598-020-72009-3

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AU - Ng, Isabel H.X.

AU - Bonthrone, Alexandra F.

AU - Kelly, Christopher J.

AU - Cordero-Grande, Lucilio

AU - Hughes, Emer J.

AU - Price, Anthony N.

AU - Hutter, Jana

AU - Victor, Suresh

AU - Schuh, Andreas

AU - Rueckert, Daniel

AU - Hajnal, Joseph V.

AU - Simpson, John

AU - Edwards, A. David

AU - Rutherford, Mary A.

AU - Batalle, Dafnis

AU - Counsell, Serena J.

PY - 2020/12/1

Y1 - 2020/12/1

N2 - Magnetic resonance (MR) imaging studies have demonstrated reduced global and regional brain volumes in infants with congenital heart disease (CHD). This study aimed to provide a more detailed evaluation of altered structural brain development in newborn infants with CHD compared to healthy controls using tensor-based morphometry (TBM). We compared brain development in 64 infants with CHD to 192 age- and sex-matched healthy controls. T2-weighted MR images obtained prior to surgery were analysed to compare voxel-wise differences in structure across the whole brain between groups. Cerebral oxygen delivery (CDO2) was measured in infants with CHD (n = 49) using phase contrast MR imaging and the relationship between CDO2 and voxel-wise brain structure was assessed using TBM. After correcting for global scaling differences, clusters of significant volume reduction in infants with CHD were demonstrated bilaterally within the basal ganglia, thalami, corpus callosum, occipital, temporal, parietal and frontal lobes, and right hippocampus (p < 0.025 after family-wise error correction). Clusters of significant volume expansion in infants with CHD were identified in cerebrospinal fluid spaces (p < 0.025). After correcting for global brain size, there was no significant association between voxel-wise brain structure and CDO2. This study localizes abnormal brain development in infants with CHD, identifying areas of particular vulnerability.

AB - Magnetic resonance (MR) imaging studies have demonstrated reduced global and regional brain volumes in infants with congenital heart disease (CHD). This study aimed to provide a more detailed evaluation of altered structural brain development in newborn infants with CHD compared to healthy controls using tensor-based morphometry (TBM). We compared brain development in 64 infants with CHD to 192 age- and sex-matched healthy controls. T2-weighted MR images obtained prior to surgery were analysed to compare voxel-wise differences in structure across the whole brain between groups. Cerebral oxygen delivery (CDO2) was measured in infants with CHD (n = 49) using phase contrast MR imaging and the relationship between CDO2 and voxel-wise brain structure was assessed using TBM. After correcting for global scaling differences, clusters of significant volume reduction in infants with CHD were demonstrated bilaterally within the basal ganglia, thalami, corpus callosum, occipital, temporal, parietal and frontal lobes, and right hippocampus (p < 0.025 after family-wise error correction). Clusters of significant volume expansion in infants with CHD were identified in cerebrospinal fluid spaces (p < 0.025). After correcting for global brain size, there was no significant association between voxel-wise brain structure and CDO2. This study localizes abnormal brain development in infants with CHD, identifying areas of particular vulnerability.

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VL - 10

JO - Scientific Reports

JF - Scientific Reports

IS - 1

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ER -

Investigating altered brain development in infants with congenital heart disease using tensor-based morphometry

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