TY - JOUR
T1 - Intravascular molecular-structural imaging with a miniaturized integrated near-infrared fluorescence and ultrasound catheter
AU - Kellnberger, Stephan
AU - Wissmeyer, Georg
AU - Albaghdadi, Mazen
AU - Piao, Zhonglie
AU - Li, Wenzhu
AU - Mauskapf, Adam
AU - Rauschendorfer, Philipp
AU - Tearney, Guillermo J.
AU - Ntziachristos, Vasilis
AU - Jaffer, Farouc A.
N1 - Publisher Copyright:
© 2021 Wiley-VCH GmbH
PY - 2021/10
Y1 - 2021/10
N2 - Coronary artery disease (CAD) remains a leading cause of mortality and warrants new imaging approaches to better guide clinical care. We report on a miniaturized, hybrid intravascular catheter and imaging system for comprehensive coronary artery imaging in vivo. Our catheter exhibits a total diameter of 1.0 mm (3.0 French), equivalent to standalone clinical intravascular ultrasound (IVUS) catheters but enables simultaneous near-infrared fluorescence (NIRF) and IVUS molecular-structural imaging. We demonstrate NIRF-IVUS imaging in vitro in coronary stents using NIR fluorophores, and compare NIRF signal strengths for prism and ball lens sensor designs in both low and high scattering media. Next, in vivo intravascular imaging in pig coronary arteries demonstrates simultaneous, co-registered molecular-structural imaging of experimental CAD inflammation on IVUS and distance-corrected NIRF images. The obtained results suggest substantial potential for the NIRF-IVUS catheter to advance standalone IVUS, and enable comprehensive phenotyping of vascular disease to better assess and treat patients with CAD.
AB - Coronary artery disease (CAD) remains a leading cause of mortality and warrants new imaging approaches to better guide clinical care. We report on a miniaturized, hybrid intravascular catheter and imaging system for comprehensive coronary artery imaging in vivo. Our catheter exhibits a total diameter of 1.0 mm (3.0 French), equivalent to standalone clinical intravascular ultrasound (IVUS) catheters but enables simultaneous near-infrared fluorescence (NIRF) and IVUS molecular-structural imaging. We demonstrate NIRF-IVUS imaging in vitro in coronary stents using NIR fluorophores, and compare NIRF signal strengths for prism and ball lens sensor designs in both low and high scattering media. Next, in vivo intravascular imaging in pig coronary arteries demonstrates simultaneous, co-registered molecular-structural imaging of experimental CAD inflammation on IVUS and distance-corrected NIRF images. The obtained results suggest substantial potential for the NIRF-IVUS catheter to advance standalone IVUS, and enable comprehensive phenotyping of vascular disease to better assess and treat patients with CAD.
KW - intravascular endoscopy
KW - intravascular imaging
KW - intravascular ultrasound
KW - near-infrared imaging
UR - http://www.scopus.com/inward/record.url?scp=85110955124&partnerID=8YFLogxK
U2 - 10.1002/jbio.202100048
DO - 10.1002/jbio.202100048
M3 - Letter
C2 - 34164943
AN - SCOPUS:85110955124
SN - 1864-063X
VL - 14
JO - Journal of Biophotonics
JF - Journal of Biophotonics
IS - 10
M1 - e202100048
ER -