INTRA/EXTRA ZELLULARES LITHIUM VERHALTNIS. KLINISCHE UND EXPERIMENTELLE BEFUNDE AN THROMBOZYTEN UND ERYTHROZYTEN

Translated title of the contribution: Intra/extracellular lithium ratio. Clinical and experimental findings on thrombocytes and erythrocytes

W. Greil, K. Schnelle, S. Seibold

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

The paper deals with three aspects of intra/extracellular lithium ratio: the effect of lithium on platelet aggregation as a function of intra/extracellular lithium content; the intra/extracellular ratio of lithium in patients varies widely interindividually, whereas variations within one individual are very small; the pharmacokinetic profiles of lithium acetate and aspartate were studied. Lithium acetate and aspartate follow the same compartmental distribution (4 compartments), when given i.v. Following oral administration the absorption of acetate was rapid and rather complete, whereas the aspartate was absorbed slowly and only as a fraction of the dose administered. The results will be further analyzed by computer techniques. According to the present results lithium aspartate has no specific affinity to the intracellular space, i.e., the aspartate lacks a specific cation carrier function for lithium.

Translated title of the contributionIntra/extracellular lithium ratio. Clinical and experimental findings on thrombocytes and erythrocytes
Original languageGerman
Pages (from-to)1079-1084
Number of pages6
JournalArzneimittel-Forschung/Drug Research
Volume24
Issue number8
StatePublished - 1974
Externally publishedYes

Fingerprint

Dive into the research topics of 'Intra/extracellular lithium ratio. Clinical and experimental findings on thrombocytes and erythrocytes'. Together they form a unique fingerprint.

Cite this