Intra-arterial catheter for simultaneous microstructural and molecular imaging in vivo

Hongki Yoo; Jin Won Kim; Milen Shishkov; Eman Namati; Theodore Morse; Roman Shubochkin; Jason R. McCarthy; Vasilis Ntziachristos; Brett E. Bouma; Farouc A. Jaffer; Guillermo J. Tearney

doi:10.1038/nm.2555

Intra-arterial catheter for simultaneous microstructural and molecular imaging in vivo

Hongki Yoo, Jin Won Kim, Milen Shishkov, Eman Namati, Theodore Morse, Roman Shubochkin, Jason R. McCarthy, Vasilis Ntziachristos, Brett E. Bouma, Farouc A. Jaffer, Guillermo J. Tearney

Chair of Biological Imaging

Research output: Contribution to journal › Article › peer-review

268 Scopus citations

Abstract

Advancing understanding of human coronary artery disease requires new methods that can be used in patients for studying atherosclerotic plaque microstructure in relation to the molecular mechanisms that underlie its initiation, progression and clinical complications, including myocardial infarction and sudden cardiac death. Here we report a dual-modality intra-arterial catheter for simultaneous microstructural and molecular imaging in vivo using a combination of optical frequency domain imaging (OFDI) and near-infrared fluorescence (NIRF) imaging. By providing simultaneous molecular information in the context of the surrounding tissue microstructure, this new catheter could provide new opportunities for investigating coronary atherosclerosis and stent healing and for identifying high-risk biological and structural coronary arterial plaques in vivo.

Original language	English
Pages (from-to)	1680-1684
Number of pages	5
Journal	Nature Medicine
Volume	17
Issue number	12
DOIs	https://doi.org/10.1038/nm.2555
State	Published - Dec 2011

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abstract = "Advancing understanding of human coronary artery disease requires new methods that can be used in patients for studying atherosclerotic plaque microstructure in relation to the molecular mechanisms that underlie its initiation, progression and clinical complications, including myocardial infarction and sudden cardiac death. Here we report a dual-modality intra-arterial catheter for simultaneous microstructural and molecular imaging in vivo using a combination of optical frequency domain imaging (OFDI) and near-infrared fluorescence (NIRF) imaging. By providing simultaneous molecular information in the context of the surrounding tissue microstructure, this new catheter could provide new opportunities for investigating coronary atherosclerosis and stent healing and for identifying high-risk biological and structural coronary arterial plaques in vivo.",

author = "Hongki Yoo and Kim, {Jin Won} and Milen Shishkov and Eman Namati and Theodore Morse and Roman Shubochkin and McCarthy, {Jason R.} and Vasilis Ntziachristos and Bouma, {Brett E.} and Jaffer, {Farouc A.} and Tearney, {Guillermo J.}",

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AU - Yoo, Hongki

AU - Kim, Jin Won

AU - Shishkov, Milen

AU - Namati, Eman

AU - Morse, Theodore

AU - Shubochkin, Roman

AU - McCarthy, Jason R.

AU - Ntziachristos, Vasilis

AU - Bouma, Brett E.

AU - Jaffer, Farouc A.

AU - Tearney, Guillermo J.

PY - 2011/12

Y1 - 2011/12

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AB - Advancing understanding of human coronary artery disease requires new methods that can be used in patients for studying atherosclerotic plaque microstructure in relation to the molecular mechanisms that underlie its initiation, progression and clinical complications, including myocardial infarction and sudden cardiac death. Here we report a dual-modality intra-arterial catheter for simultaneous microstructural and molecular imaging in vivo using a combination of optical frequency domain imaging (OFDI) and near-infrared fluorescence (NIRF) imaging. By providing simultaneous molecular information in the context of the surrounding tissue microstructure, this new catheter could provide new opportunities for investigating coronary atherosclerosis and stent healing and for identifying high-risk biological and structural coronary arterial plaques in vivo.

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Intra-arterial catheter for simultaneous microstructural and molecular imaging in vivo

Abstract

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