Intoxication due to negative canrenone interference in digoxin drug monitoring

Werner Steimer; Christine Müller; Barbara Eber; Klaus Emmanuilidis

doi:10.1016/S0140-6736(99)03818-0

Intoxication due to negative canrenone interference in digoxin drug monitoring

Werner Steimer
, Christine Müller
, Barbara Eber
, Klaus Emmanuilidis

Institute of Laboratory Medicine

Technical University of Munich

Research output: Contribution to journal › Article › peer-review

44 Scopus citations

Abstract

Canrenone and spironolactone caused falsely low readings in a common assay for digoxin (AxSym MEIA) due to negative cross-reactivity. Misleading subtarget concentrations were repeatedly reported, and falsely guided drug dosing resulted in a case of digoxin intoxication.

Original language	English
Pages (from-to)	1176-1177
Number of pages	2
Journal	The Lancet
Volume	354
Issue number	9185
DOIs	https://doi.org/10.1016/S0140-6736(99)03818-0
State	Published - 2 Oct 1999

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title = "Intoxication due to negative canrenone interference in digoxin drug monitoring",

abstract = "Canrenone and spironolactone caused falsely low readings in a common assay for digoxin (AxSym MEIA) due to negative cross-reactivity. Misleading subtarget concentrations were repeatedly reported, and falsely guided drug dosing resulted in a case of digoxin intoxication.",

author = "Werner Steimer and Christine M{\"u}ller and Barbara Eber and Klaus Emmanuilidis",

note = "Funding Information: Canrenone for in-vitro experiments was a gift from Roche Diagnostics, Mannheim, Germany. Spironolactone and canrenone concentrations were measured by Biokinet GmbH, Vienna, Austria. These measurements were supported by Heumann Pharma GmbH, N{\"u}rberg, Germany.",

year = "1999",

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doi = "10.1016/S0140-6736(99)03818-0",

language = "English",

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journal = "The Lancet",

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publisher = "Elsevier B.V.",

number = "9185",

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TY - JOUR

T1 - Intoxication due to negative canrenone interference in digoxin drug monitoring

AU - Steimer, Werner

AU - Müller, Christine

AU - Eber, Barbara

AU - Emmanuilidis, Klaus

N1 - Funding Information: Canrenone for in-vitro experiments was a gift from Roche Diagnostics, Mannheim, Germany. Spironolactone and canrenone concentrations were measured by Biokinet GmbH, Vienna, Austria. These measurements were supported by Heumann Pharma GmbH, Nürberg, Germany.

PY - 1999/10/2

Y1 - 1999/10/2

N2 - Canrenone and spironolactone caused falsely low readings in a common assay for digoxin (AxSym MEIA) due to negative cross-reactivity. Misleading subtarget concentrations were repeatedly reported, and falsely guided drug dosing resulted in a case of digoxin intoxication.

AB - Canrenone and spironolactone caused falsely low readings in a common assay for digoxin (AxSym MEIA) due to negative cross-reactivity. Misleading subtarget concentrations were repeatedly reported, and falsely guided drug dosing resulted in a case of digoxin intoxication.

UR - https://www.scopus.com/pages/publications/0345425642

U2 - 10.1016/S0140-6736(99)03818-0

DO - 10.1016/S0140-6736(99)03818-0

M3 - Article

C2 - 10513714

AN - SCOPUS:0345425642

SN - 0140-6736

VL - 354

SP - 1176

EP - 1177

JO - The Lancet

JF - The Lancet

IS - 9185

ER -

Intoxication due to negative canrenone interference in digoxin drug monitoring

Abstract

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