Intoxication due to negative canrenone interference in digoxin drug monitoring

Werner Steimer, Christine Müller, Barbara Eber, Klaus Emmanuilidis

Research output: Contribution to journalArticlepeer-review

42 Scopus citations

Abstract

Canrenone and spironolactone caused falsely low readings in a common assay for digoxin (AxSym MEIA) due to negative cross-reactivity. Misleading subtarget concentrations were repeatedly reported, and falsely guided drug dosing resulted in a case of digoxin intoxication.

Original languageEnglish
Pages (from-to)1176-1177
Number of pages2
JournalThe Lancet
Volume354
Issue number9185
DOIs
StatePublished - 2 Oct 1999

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