@article{e310042feecc424a95bc694b986cc635,
title = "Intoxication due to negative canrenone interference in digoxin drug monitoring",
abstract = "Canrenone and spironolactone caused falsely low readings in a common assay for digoxin (AxSym MEIA) due to negative cross-reactivity. Misleading subtarget concentrations were repeatedly reported, and falsely guided drug dosing resulted in a case of digoxin intoxication.",
author = "Werner Steimer and Christine M{\"u}ller and Barbara Eber and Klaus Emmanuilidis",
note = "Funding Information: Canrenone for in-vitro experiments was a gift from Roche Diagnostics, Mannheim, Germany. Spironolactone and canrenone concentrations were measured by Biokinet GmbH, Vienna, Austria. These measurements were supported by Heumann Pharma GmbH, N{\"u}rberg, Germany.",
year = "1999",
month = oct,
day = "2",
doi = "10.1016/S0140-6736(99)03818-0",
language = "English",
volume = "354",
pages = "1176--1177",
journal = "The Lancet",
issn = "0140-6736",
publisher = "Elsevier B.V.",
number = "9185",
}