Intestinal epithelial cell proteome in IL-10 deficient mice and IL-10 receptor reconstituted epithelial cells: Impact on chronic inflammation

Tanja Werner; Anna Shkoda; Dirk Haller

doi:10.1021/pr070222x

Intestinal epithelial cell proteome in IL-10 deficient mice and IL-10 receptor reconstituted epithelial cells: Impact on chronic inflammation

Tanja Werner, Anna Shkoda, Dirk Haller

Chair of Nutrition and Immunology

Technical University of Munich

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

The interaction of nonpathogenic enteric bacteria with intestinal epithelial cells (IEC) in the absence of host-derived Interleukin 10 (IL-10) may contribute to the development of chronic inflammation. Functional proteome analysis of primary IEC from Enterococcus faecalis-monoassociated WT and IL-10^-/- mice as well as IL-10 receptor reconstituted IEC revealed expression changes of proteins that are involved in endoplasmic reticulum stress, energy metabolism, and apoptosis, suggesting a protective role for IL-10 at the epithelial cell level.

Original language	English
Pages (from-to)	3691-3704
Number of pages	14
Journal	Journal of Proteome Research
Volume	6
Issue number	9
DOIs	https://doi.org/10.1021/pr070222x
State	Published - Sep 2007

Keywords

Colitogenic bacteria
Enterococcus faecalis
Epithelial cell proteome
Experimental colitis
Galectin 3
IBD
IL-10 mice
Interleukin 10
Intestinal epithelial cells

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10.1021/pr070222x

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title = "Intestinal epithelial cell proteome in IL-10 deficient mice and IL-10 receptor reconstituted epithelial cells: Impact on chronic inflammation",

abstract = "The interaction of nonpathogenic enteric bacteria with intestinal epithelial cells (IEC) in the absence of host-derived Interleukin 10 (IL-10) may contribute to the development of chronic inflammation. Functional proteome analysis of primary IEC from Enterococcus faecalis-monoassociated WT and IL-10-/- mice as well as IL-10 receptor reconstituted IEC revealed expression changes of proteins that are involved in endoplasmic reticulum stress, energy metabolism, and apoptosis, suggesting a protective role for IL-10 at the epithelial cell level.",

keywords = "Colitogenic bacteria, Enterococcus faecalis, Epithelial cell proteome, Experimental colitis, Galectin 3, IBD, IL-10 mice, Interleukin 10, Intestinal epithelial cells",

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AU - Werner, Tanja

AU - Shkoda, Anna

AU - Haller, Dirk

PY - 2007/9

Y1 - 2007/9

N2 - The interaction of nonpathogenic enteric bacteria with intestinal epithelial cells (IEC) in the absence of host-derived Interleukin 10 (IL-10) may contribute to the development of chronic inflammation. Functional proteome analysis of primary IEC from Enterococcus faecalis-monoassociated WT and IL-10-/- mice as well as IL-10 receptor reconstituted IEC revealed expression changes of proteins that are involved in endoplasmic reticulum stress, energy metabolism, and apoptosis, suggesting a protective role for IL-10 at the epithelial cell level.

AB - The interaction of nonpathogenic enteric bacteria with intestinal epithelial cells (IEC) in the absence of host-derived Interleukin 10 (IL-10) may contribute to the development of chronic inflammation. Functional proteome analysis of primary IEC from Enterococcus faecalis-monoassociated WT and IL-10-/- mice as well as IL-10 receptor reconstituted IEC revealed expression changes of proteins that are involved in endoplasmic reticulum stress, energy metabolism, and apoptosis, suggesting a protective role for IL-10 at the epithelial cell level.

KW - Colitogenic bacteria

KW - Enterococcus faecalis

KW - Epithelial cell proteome

KW - Experimental colitis

KW - Galectin 3

KW - IBD

KW - IL-10 mice

KW - Interleukin 10

KW - Intestinal epithelial cells

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SN - 1535-3893

VL - 6

SP - 3691

EP - 3704

JO - Journal of Proteome Research

JF - Journal of Proteome Research

IS - 9

ER -

Intestinal epithelial cell proteome in IL-10 deficient mice and IL-10 receptor reconstituted epithelial cells: Impact on chronic inflammation

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