INTERNATIONALE, MULTIZENTRISCHE PRUFUNG DER WIRKSAMKEIT UND VERTRAGLICHKEIT DER EXTERNEN THERAPIE CHRONISCHER EKZEME MIT EINEM 10% IGEN HARNSTOFFPRAPARAT

J. Vilaplana; P. Mohr; M. Weichenthal; H. Leonhartsberger; J. Weidenhammer; K. Gerlach; J. B. Schmidt; J. Ring; Mascaro; W. Raab

INTERNATIONALE, MULTIZENTRISCHE PRUFUNG DER WIRKSAMKEIT UND VERTRAGLICHKEIT DER EXTERNEN THERAPIE CHRONISCHER EKZEME MIT EINEM 10% IGEN HARNSTOFFPRAPARAT

Translated title of the contribution: International multicentric study on efficacy and tolerance of external treatment of chronic eczemas with a 10% urea preparation

J. Vilaplana, P. Mohr, M. Weichenthal, H. Leonhartsberger, J. Weidenhammer, K. Gerlach, J. B. Schmidt, J. Ring, Mascaro, W. Raab

Beiersdorf AG

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

In patients with chronic eczema the effects of local urea treatment on the degree of skin hydration and barrier function of the skin were studied by measuring the capacitance and transepidermal water loss (TEWL). In a multicentric trial, 43 patients with chronic eczema were treated with 10% urea for four weeks. Prior to therapy the affected skin has shown a 1.8-fold increase in TEWL as compared to normal skin. After four weeks' treatment this value decreased to 1.3-fold. Normalisation of the barrier function correlated significantly with the clinical improvement of the eczema. The value of capacitance increased significantly from 56.2% prior to therapy to 68.46 units after 4 weeks of treatment.

Translated title of the contribution	International multicentric study on efficacy and tolerance of external treatment of chronic eczemas with a 10% urea preparation
Original language	German
Pages (from-to)	227-232
Number of pages	6
Journal	Aktuelle Dermatologie
Volume	20
Issue number	6
State	Published - 1994
Externally published	Yes

Cite this

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title = "INTERNATIONALE, MULTIZENTRISCHE PRUFUNG DER WIRKSAMKEIT UND VERTRAGLICHKEIT DER EXTERNEN THERAPIE CHRONISCHER EKZEME MIT EINEM 10% IGEN HARNSTOFFPRAPARAT",

abstract = "In patients with chronic eczema the effects of local urea treatment on the degree of skin hydration and barrier function of the skin were studied by measuring the capacitance and transepidermal water loss (TEWL). In a multicentric trial, 43 patients with chronic eczema were treated with 10% urea for four weeks. Prior to therapy the affected skin has shown a 1.8-fold increase in TEWL as compared to normal skin. After four weeks' treatment this value decreased to 1.3-fold. Normalisation of the barrier function correlated significantly with the clinical improvement of the eczema. The value of capacitance increased significantly from 56.2% prior to therapy to 68.46 units after 4 weeks of treatment.",

author = "J. Vilaplana and P. Mohr and M. Weichenthal and H. Leonhartsberger and J. Weidenhammer and K. Gerlach and Schmidt, {J. B.} and J. Ring and Mascaro and W. Raab",

year = "1994",

language = "Deutsch",

volume = "20",

pages = "227--232",

journal = "Aktuelle Dermatologie",

issn = "0340-2541",

publisher = "Georg Thieme Verlag",

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T1 - INTERNATIONALE, MULTIZENTRISCHE PRUFUNG DER WIRKSAMKEIT UND VERTRAGLICHKEIT DER EXTERNEN THERAPIE CHRONISCHER EKZEME MIT EINEM 10% IGEN HARNSTOFFPRAPARAT

AU - Vilaplana, J.

AU - Mohr, P.

AU - Weichenthal, M.

AU - Leonhartsberger, H.

AU - Weidenhammer, J.

AU - Gerlach, K.

AU - Schmidt, J. B.

AU - Ring, J.

AU - Mascaro,

AU - Raab, W.

PY - 1994

Y1 - 1994

N2 - In patients with chronic eczema the effects of local urea treatment on the degree of skin hydration and barrier function of the skin were studied by measuring the capacitance and transepidermal water loss (TEWL). In a multicentric trial, 43 patients with chronic eczema were treated with 10% urea for four weeks. Prior to therapy the affected skin has shown a 1.8-fold increase in TEWL as compared to normal skin. After four weeks' treatment this value decreased to 1.3-fold. Normalisation of the barrier function correlated significantly with the clinical improvement of the eczema. The value of capacitance increased significantly from 56.2% prior to therapy to 68.46 units after 4 weeks of treatment.

AB - In patients with chronic eczema the effects of local urea treatment on the degree of skin hydration and barrier function of the skin were studied by measuring the capacitance and transepidermal water loss (TEWL). In a multicentric trial, 43 patients with chronic eczema were treated with 10% urea for four weeks. Prior to therapy the affected skin has shown a 1.8-fold increase in TEWL as compared to normal skin. After four weeks' treatment this value decreased to 1.3-fold. Normalisation of the barrier function correlated significantly with the clinical improvement of the eczema. The value of capacitance increased significantly from 56.2% prior to therapy to 68.46 units after 4 weeks of treatment.

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M3 - Artikel

AN - SCOPUS:0028228684

SN - 0340-2541

VL - 20

SP - 227

EP - 232

JO - Aktuelle Dermatologie

JF - Aktuelle Dermatologie

IS - 6

ER -

INTERNATIONALE, MULTIZENTRISCHE PRUFUNG DER WIRKSAMKEIT UND VERTRAGLICHKEIT DER EXTERNEN THERAPIE CHRONISCHER EKZEME MIT EINEM 10% IGEN HARNSTOFFPRAPARAT

Abstract

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