International collaborative validation of intraneural invasion as a prognostic marker in adenoid cystic carcinoma of the head and neck

Moran Amit; Yoav Binenbaum; Leonor Trejo-Leider; Kanika Sharma; Naomi Ramer; Ilana Ramer; Abib Agbetoba; Brett Miles; Xinjie Yang; Delin Lei; Kristine Bjørndal; Christian Godballe; Thomas Mücke; Klaus Dietrich Wolff; André M. Eckardt; Chiara Copelli; Enrico Sesenna; Frank Palmer; Ian Ganly; Snehal Patel; Ziv Gil

doi:10.1002/hed.23710

International collaborative validation of intraneural invasion as a prognostic marker in adenoid cystic carcinoma of the head and neck

Moran Amit, Yoav Binenbaum, Leonor Trejo-Leider, Kanika Sharma, Naomi Ramer, Ilana Ramer, Abib Agbetoba, Brett Miles, Xinjie Yang, Delin Lei, Kristine Bjørndal, Christian Godballe, Thomas Mücke, Klaus Dietrich Wolff, André M. Eckardt, Chiara Copelli, Enrico Sesenna, Frank Palmer, Ian Ganly, Snehal PatelZiv Gil

Chair of Odontology, in particular Oral and Maxillofacial Surgery

Research output: Contribution to journal › Article › peer-review

93 Scopus citations

Abstract

Background The purpose of this study was to characterize the incidence, pattern of spread, and prognostic correlation of nerve invasion in patients with adenoid cystic carcinoma (ACC). Methods Using 3 different pathological categories of perineural invasion, intraneural invasion, and perineural inflammation, we investigated the prognostic value of nerve invasion in a total of 495 ACCs from 9 international patient cohorts with median follow-up 90 months (range, 12-288 months). Results Of 239 patients (48%) with nerve invasion, 174 (73%) had perineural invasion, 65 (27%) intraneural invasion, and 37 (15%) perineural inflammation. Multivariate Cox regression analysis identified tumor site (p =.008; hazard ratio [HR] = 1.8; 95% confidence interval [CI] = 0.07-3.7) and intraneural invasion (p <.001; HR = 5.9; 95% CI = 0.8-12.3) as independent prognostic markers for both overall survival (OS) and disease-specific survival (DSS), but not of distant metastases. Conclusion Although perineural invasion has no impact on survival, intraneural invasion is an independent predictor of poor prognosis. Recognition of intraneural invasion may help optimize treatment of patients with head and neck ACC.

Original language	English
Pages (from-to)	1038-1045
Number of pages	8
Journal	Head and Neck
Volume	37
Issue number	7
DOIs	https://doi.org/10.1002/hed.23710
State	Published - 1 Jul 2015

Keywords

adenoid cystic carcinoma
head and neck cancer
intraneural invasion
perineural invasion
salivary gland
survival

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/hed.23710

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Amit, M., Binenbaum, Y., Trejo-Leider, L., Sharma, K., Ramer, N., Ramer, I., Agbetoba, A., Miles, B., Yang, X., Lei, D., Bjørndal, K., Godballe, C., Mücke, T., Wolff, K. D., Eckardt, A. M., Copelli, C., Sesenna, E., Palmer, F., Ganly, I., ... Gil, Z. (2015). International collaborative validation of intraneural invasion as a prognostic marker in adenoid cystic carcinoma of the head and neck. Head and Neck, 37(7), 1038-1045. https://doi.org/10.1002/hed.23710

@article{3abb2668e22c4147bfe7ab210e7cd761,

title = "International collaborative validation of intraneural invasion as a prognostic marker in adenoid cystic carcinoma of the head and neck",

abstract = "Background The purpose of this study was to characterize the incidence, pattern of spread, and prognostic correlation of nerve invasion in patients with adenoid cystic carcinoma (ACC). Methods Using 3 different pathological categories of perineural invasion, intraneural invasion, and perineural inflammation, we investigated the prognostic value of nerve invasion in a total of 495 ACCs from 9 international patient cohorts with median follow-up 90 months (range, 12-288 months). Results Of 239 patients (48%) with nerve invasion, 174 (73%) had perineural invasion, 65 (27%) intraneural invasion, and 37 (15%) perineural inflammation. Multivariate Cox regression analysis identified tumor site (p =.008; hazard ratio [HR] = 1.8; 95% confidence interval [CI] = 0.07-3.7) and intraneural invasion (p <.001; HR = 5.9; 95% CI = 0.8-12.3) as independent prognostic markers for both overall survival (OS) and disease-specific survival (DSS), but not of distant metastases. Conclusion Although perineural invasion has no impact on survival, intraneural invasion is an independent predictor of poor prognosis. Recognition of intraneural invasion may help optimize treatment of patients with head and neck ACC.",

keywords = "adenoid cystic carcinoma, head and neck cancer, intraneural invasion, perineural invasion, salivary gland, survival",

author = "Moran Amit and Yoav Binenbaum and Leonor Trejo-Leider and Kanika Sharma and Naomi Ramer and Ilana Ramer and Abib Agbetoba and Brett Miles and Xinjie Yang and Delin Lei and Kristine Bj{\o}rndal and Christian Godballe and Thomas M{\"u}cke and Wolff, {Klaus Dietrich} and Eckardt, {Andr{\'e} M.} and Chiara Copelli and Enrico Sesenna and Frank Palmer and Ian Ganly and Snehal Patel and Ziv Gil",

note = "Publisher Copyright: {\textcopyright} 2014 Wiley Periodicals, Inc.",

year = "2015",

month = jul,

day = "1",

doi = "10.1002/hed.23710",

language = "English",

volume = "37",

pages = "1038--1045",

journal = "Head and Neck",

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Amit, M, Binenbaum, Y, Trejo-Leider, L, Sharma, K, Ramer, N, Ramer, I, Agbetoba, A, Miles, B, Yang, X, Lei, D, Bjørndal, K, Godballe, C, Mücke, T, Wolff, KD, Eckardt, AM, Copelli, C, Sesenna, E, Palmer, F, Ganly, I, Patel, S & Gil, Z 2015, 'International collaborative validation of intraneural invasion as a prognostic marker in adenoid cystic carcinoma of the head and neck', Head and Neck, vol. 37, no. 7, pp. 1038-1045. https://doi.org/10.1002/hed.23710

TY - JOUR

T1 - International collaborative validation of intraneural invasion as a prognostic marker in adenoid cystic carcinoma of the head and neck

AU - Amit, Moran

AU - Binenbaum, Yoav

AU - Trejo-Leider, Leonor

AU - Sharma, Kanika

AU - Ramer, Naomi

AU - Ramer, Ilana

AU - Agbetoba, Abib

AU - Miles, Brett

AU - Yang, Xinjie

AU - Lei, Delin

AU - Bjørndal, Kristine

AU - Godballe, Christian

AU - Mücke, Thomas

AU - Wolff, Klaus Dietrich

AU - Eckardt, André M.

AU - Copelli, Chiara

AU - Sesenna, Enrico

AU - Palmer, Frank

AU - Ganly, Ian

AU - Patel, Snehal

AU - Gil, Ziv

PY - 2015/7/1

Y1 - 2015/7/1

N2 - Background The purpose of this study was to characterize the incidence, pattern of spread, and prognostic correlation of nerve invasion in patients with adenoid cystic carcinoma (ACC). Methods Using 3 different pathological categories of perineural invasion, intraneural invasion, and perineural inflammation, we investigated the prognostic value of nerve invasion in a total of 495 ACCs from 9 international patient cohorts with median follow-up 90 months (range, 12-288 months). Results Of 239 patients (48%) with nerve invasion, 174 (73%) had perineural invasion, 65 (27%) intraneural invasion, and 37 (15%) perineural inflammation. Multivariate Cox regression analysis identified tumor site (p =.008; hazard ratio [HR] = 1.8; 95% confidence interval [CI] = 0.07-3.7) and intraneural invasion (p <.001; HR = 5.9; 95% CI = 0.8-12.3) as independent prognostic markers for both overall survival (OS) and disease-specific survival (DSS), but not of distant metastases. Conclusion Although perineural invasion has no impact on survival, intraneural invasion is an independent predictor of poor prognosis. Recognition of intraneural invasion may help optimize treatment of patients with head and neck ACC.

AB - Background The purpose of this study was to characterize the incidence, pattern of spread, and prognostic correlation of nerve invasion in patients with adenoid cystic carcinoma (ACC). Methods Using 3 different pathological categories of perineural invasion, intraneural invasion, and perineural inflammation, we investigated the prognostic value of nerve invasion in a total of 495 ACCs from 9 international patient cohorts with median follow-up 90 months (range, 12-288 months). Results Of 239 patients (48%) with nerve invasion, 174 (73%) had perineural invasion, 65 (27%) intraneural invasion, and 37 (15%) perineural inflammation. Multivariate Cox regression analysis identified tumor site (p =.008; hazard ratio [HR] = 1.8; 95% confidence interval [CI] = 0.07-3.7) and intraneural invasion (p <.001; HR = 5.9; 95% CI = 0.8-12.3) as independent prognostic markers for both overall survival (OS) and disease-specific survival (DSS), but not of distant metastases. Conclusion Although perineural invasion has no impact on survival, intraneural invasion is an independent predictor of poor prognosis. Recognition of intraneural invasion may help optimize treatment of patients with head and neck ACC.

KW - adenoid cystic carcinoma

KW - head and neck cancer

KW - intraneural invasion

KW - perineural invasion

KW - salivary gland

KW - survival

UR - http://www.scopus.com/inward/record.url?scp=84931564541&partnerID=8YFLogxK

U2 - 10.1002/hed.23710

DO - 10.1002/hed.23710

M3 - Article

C2 - 24710845

AN - SCOPUS:84931564541

SN - 1043-3074

VL - 37

SP - 1038

EP - 1045

JO - Head and Neck

JF - Head and Neck

IS - 7

ER -

International collaborative validation of intraneural invasion as a prognostic marker in adenoid cystic carcinoma of the head and neck

Abstract

Keywords

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